Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing, 210098, China.
Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing, 210098, China.
Ecotoxicol Environ Saf. 2020 Jun 1;195:110470. doi: 10.1016/j.ecoenv.2020.110470. Epub 2020 Mar 18.
Natural aquatic colloids play an important role in the migration, transformation of pollutants in the environment, but their potential effects are often ignored in ecotoxicology research. In this study, diclofenac (DCF) was selected as a typical drug to study the effects of natural colloids on the bioaccumulation and biotoxicity in juvenile zebrafish (Danio rerio) exposed to an environmentally relevant concentration (1 μg/L) and a high concentration (100 μg/L) of DCF. The results showed that the presence of colloids accelerated and enhanced the accumulation of DCF in zebrafish muscle and viscera, and the effects are greater at the environmentally relevant concentration of DCF. However, the colloids enhanced the burden in the head in the environmentally relevant concentration group, but reduced it in the high concentration group. This observation may be related to the occurrence of variations in the contribution of the adsorption forms of DCF and the colloids depending on different DCF concentrations. At the same time, the presence of colloids can significantly induce AChE activity of DCF in the brain and alter swimming activity and shoaling behaviour of the individuals, however no significant effects on the attack and shock behaviour were observed. These findings indicate that the combination of natural colloids and pollutants may change with pollutant concentrations, thereby altering the bioaccumulation and biological effects in aquatic organisms.
天然水胶体在环境中污染物的迁移、转化中起着重要作用，但它们的潜在影响在生态毒理学研究中往往被忽视。在本研究中，选择双氯芬酸（DCF）作为典型药物，研究天然胶体对暴露于环境相关浓度（1μg/L）和高浓度（100μg/L）DCF 的幼年斑马鱼（Danio rerio）中生物积累和生物毒性的影响。结果表明，胶体的存在加速并增强了 DCF 在斑马鱼肌肉和内脏中的积累，并且在环境相关浓度的 DCF 下效果更大。然而，胶体在环境相关浓度组中增强了头部的负担，但在高浓度组中降低了。这种观察可能与不同 DCF 浓度下 DCF 和胶体的吸附形式的变化有关。同时，胶体的存在可以显著诱导 DCF 在大脑中的 AChE 活性，并改变个体的游泳和聚集行为，但对攻击和震惊行为没有显著影响。这些发现表明，天然胶体和污染物的结合可能随污染物浓度而变化，从而改变水生生物中的生物积累和生物效应。
