激肽释放酶 6 调控途径揭示了水痘带状疱疹病毒感染新的潜在靶点。

Kallikrein-6-Regulated Pathways Shed Light on New Potential Targets in Varicella Zoster Virus Infection.

机构信息

Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Dermatology, Women's College Hospital, Toronto, Ontario, Canada.

出版信息

J Invest Dermatol. 2020 Apr;140(4):741-742. doi: 10.1016/j.jid.2019.11.006.

DOI:10.1016/j.jid.2019.11.006

PMID:32200876

Abstract

Varicella zoster virus, the worldwide infectious human virus responsible for acute varicella and chickenpox, commonly spreads from exposure through contact with a skin lesion or airborne respiratory droplets. Keratinocytes, major targets and source of transmission of the virus present in the skin, represent an ideal choice of cell to stop early virus progression. In their recent study, Tommasi et al. show regulatory mechanisms of cytokeratin 10 through the protease kallikrein-6 as a suitable and druggable pathway to reduce varicella zoster virus dissemination.

摘要

水痘带状疱疹病毒是一种全球性的传染性人类病毒，可引起急性水痘和带状疱疹，通常通过接触皮肤损伤或空气传播的飞沫传播。角蛋白细胞是病毒在皮肤中的主要靶细胞和传播源，是阻止病毒早期进展的理想选择。在他们最近的研究中，Tommasi 等人展示了通过蛋白酶激肽释放酶 6对细胞角蛋白 10 的调控机制，这是一种减少水痘带状疱疹病毒传播的合适且可成药的途径。