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肿瘤“旅行团”——为何循环癌细胞喜欢“结伴而行”

Tumour travel tours - Why circulating cancer cells value company.

作者信息

Häfner Sophia Julia

机构信息

University of Copenhagen, BRIC Biotech Research & Innovation Centre, Anders Lund Group, Copenhagen, Denmark.

出版信息

Biomed J. 2020 Feb;43(1):1-7. doi: 10.1016/j.bj.2020.02.001. Epub 2020 Feb 24.

DOI:10.1016/j.bj.2020.02.001
PMID:32200951
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7090313/
Abstract

Welcome to the New Year and a new issue of the Biomedical Journal, where we learn that travelling with company boosts the metastatic potential of circulating tumour cells, as well as that a worm could be an excellent model to study antidiabetic drugs. In addition, we discover another pair of molecular scissors for genetic engineering, how exactly Leptospira wreaks havoc on its run through the host organism, and that hyperparathyroidism brings its own risks, but does not worsen the outcome of papillary thyroid carcinoma. Furthermore, the importance of taking into account differing beauty ideals for aesthetic surgery surveys is discussed, alongside the question how bad isolated local recurrence is in the case of HR + breast cancer. Finally, we find out that virtual colonoscopy deserves more credit, that the first medical experiment in space was all about the H-reflex, and that it is possible to survive advanced necrotising fasciitis of the face and neck.

摘要

欢迎来到新的一年,以及《生物医学杂志》的新一期。在本期中,我们了解到结伴旅行会增加循环肿瘤细胞的转移潜能,同时一种蠕虫可能是研究抗糖尿病药物的优秀模型。此外,我们发现了另一对用于基因工程的分子剪刀,钩端螺旋体在宿主生物体中肆虐的具体方式,以及甲状旁腺功能亢进会带来自身风险,但不会使甲状腺乳头状癌的预后恶化。此外,还讨论了在美容手术调查中考虑不同审美观念的重要性,以及HR +乳腺癌孤立局部复发的严重程度问题。最后,我们发现虚拟结肠镜检查值得更多认可,太空首次医学实验完全是关于H反射的,并且面部和颈部晚期坏死性筋膜炎患者有可能存活下来。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6da4/7090313/b7a904bc36fb/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6da4/7090313/b7a904bc36fb/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6da4/7090313/b7a904bc36fb/gr1.jpg

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Biomed J. 2020 Feb;43(1):83-93. doi: 10.1016/j.bj.2019.07.002. Epub 2020 Feb 21.
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CRISPR-Cas12a: Functional overview and applications.
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Biomed J. 2020 Feb;43(1):74-82. doi: 10.1016/j.bj.2019.07.006. Epub 2020 Feb 25.
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