中东呼吸综合征：发病机制与治疗进展
Middle East respiratory syndrome: pathogenesis and therapeutic developments.
作者信息
Choudhry Hani, Bakhrebah Muhammed A, Abdulaal Wesam H, Zamzami Mazin A, Baothman Othman A, Hassan Mohammed A, Zeyadi Mustafa, Helmi Nawal, Alzahrani Faisal, Ali Ashraf, Zakaria Mohammad Khalid, Kamal Mohammad Azhar, Warsi Mohiuddin Khan, Ahmed Firoz, Rasool Mahmood, Jamal Mohammad Sarwar
机构信息
Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Life Science & environment Research Institute, National Center for Genome Technology, King Abdulaziz City for Science and Technology (KACST), Riyadh 12371, Saudi Arabia.
出版信息
Future Virol. 2019 Apr;14(4):237-246. doi: 10.2217/fvl-2018-0201. Epub 2019 Apr 18.
The first case of Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in the year 2012, which spread rapidly and increased to more than 2200 in 2018. This highly pathogenic virus with high mortality rate is among one of the major public health concerns. Saudi Arabia remains to be the most affected region with the majority of MERS-CoV cases, and currently, no effective drugs and vaccines are available for prevention and treatment. A large amount of information is now available regarding the virus, its structure, route of transmission and its pathophysiology. Therefore, this review summarizes the current understanding of MERS-CoV's pathogenesis, treatment options and recent scientific advancements in vaccine and other therapeutic developments, and the major steps taken for MERS prevention control.
中东呼吸综合征冠状病毒（MERS-CoV）的首例病例于2012年被确认，该病毒迅速传播，到2018年病例数增至2000多例。这种高致病性且死亡率高的病毒是主要的公共卫生问题之一。沙特阿拉伯仍然是受影响最严重的地区，MERS-CoV病例占大多数，目前尚无有效的预防和治疗药物及疫苗。现在已有大量关于该病毒、其结构、传播途径及病理生理学的信息。因此，本综述总结了目前对MERS-CoV发病机制、治疗选择以及疫苗和其他治疗进展方面的最新科学进展，以及为预防控制MERS采取的主要措施。
Zotero 插件