Deen Surrin S, Boyes Jennifer, Oyewole Bankole, Bahk Anna, Thomas George, Gunathilagan Gunaratnam
East Kest Hospitals University NHS Trust, Margate, United Kingdom.
BJR Case Rep. 2020 Feb 12;6(1):20190068. doi: 10.1259/bjrcr.20190068. eCollection 2020 Mar.
is the third most frequent cause of bacterial meningitis and has a predilection for elderly patients and the immunosuppressed. A small number of patients with meningoencephalitis have previously been reported to experience stroke-like symptoms that were attributed to microabscess formation and the mass effect of collections of infection in the brain. These infections led to temporary neurological deficits that resolved with antimicrobial treatment, rather than to true strokes with permanent neurological deficits. This report discusses the case of an 80- year-old male, who was immunosuppressed with mesalazine for the treatment of Crohn's disease, and who went on to develop meningoencephalitis. 1 week into his admission, for antibiotic therapy, the patient began to experience new onset right upper limb weakness, nystagmus and past pointing. These symptoms were initially thought to be a complication of the infection. However, subsequent diffusion-weighted MRI revealed that the patient had more likely suffered an acute ischaemic event and a contrast-enhanced MRI performed later could not detect any abscess or large infective focus in a region that could explain the symptoms. This case report highlights the fact that ischaemic and infective pathologists may coexist in immunosuppressed Listeria patients and that clinical signs and symptoms should guide the use of appropriate imaging modalities such as MRI to clarify differentials so that ischaemia is not mistaken for the more common stroke mimic caused by infection in these patients.
是细菌性脑膜炎的第三大常见病因,好发于老年患者和免疫功能低下者。此前有少数脑膜脑炎患者曾出现类似中风的症状,这些症状被归因于微脓肿形成以及脑部感染灶的占位效应。这些感染导致了暂时性神经功能缺损,经抗菌治疗后得以缓解,而非导致伴有永久性神经功能缺损的真正中风。本报告讨论了一例80岁男性患者的病例,该患者因治疗克罗恩病而服用美沙拉嗪导致免疫功能低下,继而发展为脑膜脑炎。在其入院接受抗生素治疗1周后,患者开始出现新发的右上肢无力、眼球震颤和指物偏向。这些症状最初被认为是感染的并发症。然而,随后的弥散加权磁共振成像显示,该患者更有可能发生了急性缺血性事件,且稍后进行的增强磁共振成像未能在可解释这些症状的区域检测到任何脓肿或大的感染灶。本病例报告强调了这样一个事实,即缺血性和感染性病变可能在免疫功能低下的李斯特菌病患者中共存,临床体征和症状应指导使用适当的成像方式,如磁共振成像,以明确鉴别诊断,从而避免在这些患者中将缺血误认为是由感染引起的更常见的类似中风表现。