1例杜波伊斯组织胞浆菌脑脓肿病例及文献复习
A Case of Histoplasma duboisii Brain Abscess and Review of the Literature.
作者信息
Konan Landry, Drogba Landry, Brahima Doukoure, Mesfin Fassil B
机构信息
Anatomy and Neurosurgery, University Felix Houphouet Boigny, Abidjan, CIV.
Neurosurgery, School of Medicine at the University of Abidjan, Abidjan, CIV.
出版信息
Cureus. 2020 Feb 13;12(2):e6984. doi: 10.7759/cureus.6984.
Histoplasmosis is a fungal disease caused by var. (Hcc) and var. (Hcd)Central nervous system (CNS) involvement is rare. So far, the few cases reported having Histoplasmosis associated brain abscesses were caused by var. . Herein, we report a unique case of brain abscess caused by var. occurring in a 42-year-old immunocompromised woman with HIV. Initially, she presented with hypothermia, vomiting, frontal headache, evolving over one month. She then progressed to have a generalized seizure. Brain MRI showed multifocal brain abscesses and a frontal osteitis. The frontal osteitis was biopsied and confirmed the diagnosis of var. . She was successfully treated with liposomal amphotericin B (150 mg daily) for the first four weeks and itraconazole (200mg twice daily) for six months.
组织胞浆菌病是一种由荚膜组织胞浆菌变种（Hcc）和皮炎组织胞浆菌变种（Hcd）引起的真菌病。中枢神经系统（CNS）受累较为罕见。到目前为止，少数报告的患有组织胞浆菌病相关脑脓肿的病例是由荚膜组织胞浆菌变种引起的。在此，我们报告一例由皮炎组织胞浆菌变种引起的脑脓肿的独特病例，该病例发生在一名42岁的HIV免疫功能低下女性身上。最初，她出现体温过低、呕吐、前额头痛，持续了一个多月。随后她发展为全身性癫痫发作。脑部MRI显示多灶性脑脓肿和额骨炎。对额骨炎进行活检并确诊为皮炎组织胞浆菌变种。她最初四周成功接受了脂质体两性霉素B（每日150毫克）治疗，随后六个月接受了伊曲康唑（每日两次，每次200毫克）治疗。
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