糖尿病大鼠动脉内皮细胞表面负电荷减少。
Reduced negative surface charge on arterial endothelium of diabetic rats.
作者信息
Raz I, Havivi Y, Yarom R
机构信息
Department of Medicine B, Hadassah University Hospital, Jerusalem, Israel.
出版信息
Diabetologia. 1988 Aug;31(8):618-20. doi: 10.1007/BF00264770.
PMID:3220197
Abstract
Cationized ferritin binding was used to measure negative surface charge on endothelium of large arteries in streptozotocin-induced diabetic rats and normal control rats. The negative charge was significantly lower in the diabetic animals (p less than 0.01). This change, possibly related to glycosylation, may lead to altered vascular permeability and may be of importance in the vascular pathology of diabetes.
摘要
用阳离子铁蛋白结合法测定链脲佐菌素诱导的糖尿病大鼠和正常对照大鼠大动脉内皮细胞的表面负电荷。糖尿病动物的负电荷明显降低（p<0.01）。这种变化可能与糖基化有关，可能导致血管通透性改变，在糖尿病血管病变中可能具有重要意义。
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