State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China.
College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, P. R. China.
J Org Chem. 2020 Apr 17;85(8):5511-5515. doi: 10.1021/acs.joc.0c00272. Epub 2020 Apr 1.
Two sesterterpenoids, possessing an unusual 10,11--gentianellane skeleton, gentianelloids A and B, were isolated from a traditional Uighur medicine . Through extensive spectroscopic analysis and single-crystal X-ray diffraction, their structures including absolute configurations were unambiguously determined. A plausible biosynthetic pathway for the two compounds was proposed. Both compounds showed remarkable immunosuppressive activity, including inhibition of the proliferation, activation, and cytokine IFN-γ production of T cells. The findings suggested that sesterterpenoids could contribute positively to the therapeutic effects of this popular traditional Uighur medicine.
从一种传统的维吾尔药中分离得到了两个具有不寻常 10,11--龙胆烷骨架的倍半萜类化合物，命名为龙胆烷 A 和 B。通过广泛的光谱分析和单晶 X 射线衍射，明确了它们的结构，包括绝对构型。提出了这两个化合物的可能生物合成途径。这两种化合物均表现出显著的免疫抑制活性，包括抑制 T 细胞的增殖、活化和细胞因子 IFN-γ 的产生。研究结果表明，倍半萜类化合物可能对这种流行的传统维吾尔药的治疗效果有积极贡献。
