Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Phytochemistry. 2021 Nov;191:112910. doi: 10.1016/j.phytochem.2021.112910. Epub 2021 Sep 1.
Ten sesterterpenoids, including eight undescribed ones named spectanoids A-H and two known analogs, were obtained from Aspergillus spectabilis. Their structures, including absolute configurations, were determined based on HRESIMS, NMR, ECD calculations and single-crystal X-ray diffraction analyses. Spectanoids A-G are tricyclic sesterterpenoids with an unusual 5/12/5 ring system, while spectanoid H possesses a 5/8/6/5 ring system. All of these compounds were evaluated for their cytotoxic activities against three human cancer cells, and spectanoid A, spectanoid C and spectanoid F exhibited moderate cytotoxic activities with IC values ranging from 12.1 to 26.1 μM.
从土曲霉中分离得到了 10 个倍半萜类化合物，包括 8 个新化合物命名为 spectanoids A-H 和 2 个已知类似物。基于高分辨质谱（HRESIMS）、核磁共振（NMR）、ECD 计算和单晶 X 射线衍射分析确定了它们的结构，包括绝对构型。spectanoids A-G 是具有不寻常的 5/12/5 环系统的三环倍半萜，而 spectanoid H 具有 5/8/6/5 环系统。所有这些化合物都被评估了对三种人类癌细胞的细胞毒性活性，spectanoid A、spectanoid C 和 spectanoid F 表现出中等的细胞毒性活性，IC 值范围为 12.1 至 26.1 μM。
