Artero Morà A, Lluch Hernandez A, Cano Sanchez A, Bueno Cañigral F J, Martin Quetglas G, Alberola Candel V, Garcia-Conde Bru J
Servicio de Hematología y Oncologia Medica, Hospital Clínico Universitario, Valencia, Spain.
Tumori. 1989 Apr 30;75(2):113-6. doi: 10.1177/030089168907500207.
An immunoradiometric assay was used to determine the presence of p29 protein in 68 breast cancer cyTOSOLS. The p29 values ranged from 0 to 1123 U/mg, with a mean value of 127 +/- 28.7 U/mg. Using a cutoff point of 20 U/mg the frequency of p29 positive tumors was about 55%. A quantitative and qualitative relation was found between p29 and estrogen receptor (ER), but not between p29 and progesterone receptor (PR). Discordance between p29 and ER status was found in 13 out of 68 tumors. Both the frequency of p29 positive tumors and the p29 values were significantly higher in postmenopausal than in premenopausal women, in a similar way to ER but different from PR. There was no difference in p29 content between primary tumor and metastasis. We did not find any relation among p29 primary tumors content and axillary lymph nodes involvement or tumor size.
采用免疫放射分析方法测定68例乳腺癌细胞溶胶中p29蛋白的存在情况。p29值范围为0至1123 U/mg，平均值为127±28.7 U/mg。以20 U/mg为临界值，p29阳性肿瘤的频率约为55%。发现p29与雌激素受体（ER）之间存在定量和定性关系，但p29与孕激素受体（PR）之间不存在这种关系。68例肿瘤中有13例p29与ER状态不一致。绝经后女性p29阳性肿瘤的频率和p29值均显著高于绝经前女性，这与ER情况相似，但与PR不同。原发肿瘤和转移灶之间的p29含量没有差异。我们未发现p29原发肿瘤含量与腋窝淋巴结受累情况或肿瘤大小之间存在任何关系。
