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黑色素在黑真菌中在发病机理和环境生存方面的作用。

The role of melanins in melanotic fungi for pathogenesis and environmental survival.

机构信息

Department of Natural Sciences, Baruch College of The City University of New York, 17 Lexington Avenue, New York, NY, 10010, USA.

Graduate Center of the City University of New York, PhD Program in Biology, The City University of New York, 365 Fifth Avenue, New York, NY, 10016, USA.

出版信息

Appl Microbiol Biotechnol. 2020 May;104(10):4247-4257. doi: 10.1007/s00253-020-10532-z. Epub 2020 Mar 23.

Abstract

Melanins provide fungi protection from environmental stressors, support their ecological roles, and can confer virulence in pathogens. While the function, structure, and synthesis of melanins in fungi are not fully understood, they have been shown to have varied roles. Recent research has revealed a wide range of functions, from radiation resistance to increasing virulence, shedding light on fungal diversity. Understanding fungal melanins can provide useful information, from harnessing the properties of these various melanins to targeting fungal infections.Key Points• Melanotic fungi are widespread in nature. • Melanin functions to protect fungi in the environment from a range of stresses. • Melanin contributes to pathogenesis and drug resistance of pathogenic fungi.

摘要

黑色素使真菌能够抵御环境胁迫,支持其生态角色,并在病原体中赋予毒力。虽然真菌中黑色素的功能、结构和合成尚未完全了解,但已显示出其具有多种作用。最近的研究揭示了一系列广泛的功能,从辐射抗性到增加毒力,揭示了真菌的多样性。了解真菌黑色素可以提供有用的信息,从利用这些不同黑色素的特性到靶向真菌感染。

关键点

  • 产黑色素真菌在自然界中广泛存在。

  • 黑色素的功能是保护真菌免受各种压力的环境影响。

  • 黑色素有助于致病性真菌的发病机制和耐药性。

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