Department of Pathology, China-Japan Friendship Hospital, Beijing, China.
Department of Gynecology and Obstetrics, Changping Hospital of Chinese and Western Medicine, Beijing, China.
Cell Transplant. 2020 Jan-Dec;29:963689720905506. doi: 10.1177/0963689720905506.
Ovarian cancer (OC) is the most aggressive gynecological cancer. Even with the advances in detection and therapeutics, it still remains clinically challenging and there is a pressing need to identify novel therapeutic strategies. In searching for rational molecular targets, we identified metadherin (MTDH), a multifunctional gene associated with several tumor types but previously unrecognized in OC. In this study, we found the MTDH is overexpressed in OC tissues. Through in vitro assays with overexpression cells, we characterized the role of MTDH. We confirmed MTDH stable overexpression significantly increased the expression of TNF-α, IL-6, IL-8, IL-10, and IL-1β. Interestingly, NF-kappa-B (NF-κB) and MTDH were found in a feed-forward loop motif. Thus, our findings support the notion that the MTDH and NF-κB signaling network contributes to OC traits. MTDH represents a new OC-associated gene that can contribute to insights of OC biology and suggests other treatment strategies.
卵巢癌（OC）是最具侵袭性的妇科癌症。即使在检测和治疗方面取得了进展，它仍然具有临床挑战性，迫切需要确定新的治疗策略。在寻找合理的分子靶点时，我们发现了黏附素（MTDH），这是一种与多种肿瘤类型相关的多功能基因，但以前在 OC 中未被识别。在这项研究中，我们发现 MTDH 在 OC 组织中过度表达。通过过表达细胞的体外实验，我们对 MTDH 的作用进行了特征描述。我们证实 MTDH 的稳定过表达显著增加了 TNF-α、IL-6、IL-8、IL-10 和 IL-1β的表达。有趣的是，NF-κB（NF-κB）和 MTDH 被发现存在正反馈环模式。因此，我们的研究结果支持了这样一种观点，即 MTDH 和 NF-κB 信号网络有助于 OC 特征的形成。MTDH 代表了一个新的与 OC 相关的基因，它可以为 OC 生物学提供新的见解，并为其他治疗策略提供思路。
