Osnovina I P, Alekseeva N V, Gerasimenko M Yu
Ivanovo State Medical Academy, Ivanovo, Russia.
Russian Medical Academy of Continuing Professional Education, Moscow, Russia.
Vopr Kurortol Fizioter Lech Fiz Kult. 2020;97(1):42-50. doi: 10.17116/kurort20209701142.
Treatment of osteoarthritis (OA) is a relevant problem of rheumatology. Despite a significant number of medical approaches and the creation of new drugs, the effectiveness of treatment remains unsatisfactory, which necessitates the creation of complex treatment programs. Pulse low-frequency magnetotherapy is a modern method that makes it possible to potentiate the therapeutic effects of chondroprotectors for transdermal administration using magnetophoresis technology.
To evaluate the efficacy and tolerability of combination therapy using chondroprotective magnetophoresis using 'running' pulsed magnetic field (RPMF) and application of chondroxide (transdermal gel form) in patients with knee OA.
A randomized, placebo-controlled clinical trial included 65 patients with grade II - III knee OA according to the Kellgren-Lwrence classification. The 1st group included 25 patients who received local therapy - chondroxide magnetophoresis using RPMF (20 mT, frequency 6.25 Hz, exposure time 20 min, No. 12); in the 2nd group - 20 patients who underwent placebo-magnetotherapy of chondroxide; in the 3rd group - 20 patients who used RPMF without local chondroprotective therapy. We used VAS, WOMAC scales, EQ-5D questionnaire, OMERACT-OARSI criterion in order to analyze the results.
A pronounced analgesic effect of the treatment was registered (according to the VAS and WOMAC scales) in patients receiving magnetotherapy (p<0.01). A significant improvement in functional parameters (according to WOMAC) was noted, more pronounced in patients who used chondroxide magnetophoresis (p<0.001). During the course of treatment, a positive effect of magnetotherapy on the indicators of quality of life (according to EQ-5D) was registered. A high percentage of response (68.1%) to therapy using magnetophoresis of the transdermal form of chondroxide (according to OMERACT-OARSI) was demonstrated. No adverse reactions were registered during treatment.
The use of the local therapy method in the form of magnetophoresis of the transdermal form of the chondroxide is an effective and safe treatment technology that improves the functional state and quality of life of patients with OA of the knee joint.
骨关节炎（OA）的治疗是风湿病学中的一个重要问题。尽管有大量的医学方法和新药问世，但治疗效果仍不尽人意，这就需要制定综合治疗方案。脉冲低频磁疗法是一种现代方法，它能够利用磁泳技术增强软骨保护剂经皮给药的治疗效果。
评估采用“运行”脉冲磁场（RPMF）的软骨保护磁泳疗法与应用chondroxide（透皮凝胶剂型）联合治疗膝骨关节炎患者的疗效和耐受性。
一项随机、安慰剂对照临床试验纳入了65例根据Kellgren-Lwrence分类为II - III级膝骨关节炎患者。第一组包括25例接受局部治疗的患者——使用RPMF进行chondroxide磁泳治疗（20 mT，频率6.25 Hz，照射时间20分钟，第12号）；第二组包括20例接受chondroxide安慰剂磁疗的患者；第三组包括20例未进行局部软骨保护治疗仅使用RPMF的患者。我们使用视觉模拟评分法（VAS）、西安大略和麦克马斯特大学骨关节炎指数（WOMAC）量表、欧洲五维度健康量表（EQ-5D）问卷、骨关节炎研究学会国际工作组（OMERACT-OARSI）标准来分析结果。
接受磁疗的患者（根据VAS和WOMAC量表）显示出明显的镇痛效果（p<0.01）。观察到功能参数有显著改善（根据WOMAC），在使用chondroxide磁泳疗法的患者中更为明显（p<0.001）。在治疗过程中，磁疗对生活质量指标（根据EQ-5D）产生了积极影响。使用chondroxide透皮剂型磁泳疗法的治疗反应率较高（68.1%，根据OMERACT-OARSI）。治疗期间未记录到不良反应。
采用chondroxide透皮剂型磁泳疗法的局部治疗方法是一种有效且安全的治疗技术，可改善膝关节骨关节炎患者的功能状态和生活质量。
