† These authors contributed equally to this work.
Biomed Mater. 2020 Jun 29;15(4):045021. doi: 10.1088/1748-605X/ab82ea.
Current tissue engineering techniques have been intensively focused on creating injectable systems that can be used in minimally invasive surgery and controlled local drug delivery applications. The materials developed so far are based on natural and synthetic polymers and their nanocomposites, but many of them fail to simultaneously provide mechanical stability, stretchability and enhanced cell adhesiveness. In this context, to generate advanced injectable nanocomposite polymers that concurrently possess several properties, we used nanomaterials as well as nanomaterials that are chemically functionalized with bioactive molecules. Our 3D-printed polymer/nanomaterial composites (nanocomposite polymers) displayed enhanced mechanical properties, good shape fidelity, non-toxicity, stretchability, biostability and cell adhesiveness.
目前，组织工程技术一直集中在开发可用于微创手术和局部药物控释应用的可注射系统上。迄今为止开发的材料基于天然和合成聚合物及其纳米复合材料，但其中许多材料都不能同时提供机械稳定性、拉伸性和增强的细胞黏附性。在这种情况下，为了生成同时具有多种特性的先进的可注射纳米复合材料聚合物，我们使用了纳米材料以及用生物活性分子化学功能化的纳米材料。我们的 3D 打印聚合物/纳米材料复合材料（纳米复合材料聚合物）表现出增强的机械性能、良好的形状保真度、无毒、拉伸性、生物稳定性和细胞黏附性。
