Physikalisches Institute and Center for Soft Nanoscience, Westfälische Wilhelms-Universität Münster, Busse-Peus-Strasse 10, 48149 Münster, Germany.
Institut für Molekulare Mikrobiologie und Biotechnologie, Westfälische Wilhelms-Universität Münster, Corrensstrasse 3, 48149 Münster, Germany.
Biomed Mater. 2021 Feb 18;16(2):025013. doi: 10.1088/1748-605X/abd872.
In the biomedical field, silicon-based materials are widely used as implants, biomedical devices, and drug delivery systems. Although these materials show promise for implant technologies and clinical applications, many of them fail to simultaneously possess key properties, such as mechanical stability, biostability, stretchability, cell adhesiveness, biofilm inhibition, and drug delivery ability. Therefore, there is considerable need for the development and improvement of new biomaterials with improved properties. In this context, we describe the synthesis of a new hybrid nanocomposite material that is prepared by incorporating bifunctional nanomaterials onto glass and polydimethylsiloxane surfaces. The results show that our hybrid nanocomposite material is elastic, stretchable, injectable, biostable, has pH-controlled drug delivery ability, and display improved cell adhesion and proliferation and, at the same time, impacted bacterial biofilm formation on the respective surfaces.
在生物医学领域，基于硅的材料被广泛用作植入物、生物医学设备和药物输送系统。尽管这些材料在植入技术和临床应用方面显示出了潜力，但它们中的许多材料都未能同时具备机械稳定性、生物稳定性、可拉伸性、细胞黏附性、生物膜抑制和药物输送能力等关键特性。因此，开发和改进具有改善性能的新型生物材料具有重要意义。在这种情况下，我们描述了一种新的杂化纳米复合材料的合成方法，该方法通过将双功能纳米材料掺入玻璃和聚二甲基硅氧烷表面来制备。结果表明，我们的杂化纳米复合材料具有弹性、可拉伸性、可注射性、生物稳定性、具有 pH 控制的药物输送能力，并显示出改善的细胞黏附和增殖能力，同时还能抑制各自表面的细菌生物膜形成。
