3B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark-Parque de Ciência e Tecnologia, Barco, 4805-017, Guimarães, Portugal.
ICVS/3B's, Associate PT Government Laboratory, Braga/Guimarães, Portugal.
J Nanobiotechnology. 2020 Jan 30;18(1):23. doi: 10.1186/s12951-019-0556-1.
Ligaments and tendons are fibrous tissues with poor vascularity and limited regeneration capacity. Currently, a ligament/tendon injury often require a surgical procedure using auto- or allografts that present some limitations. These inadequacies combined with the significant economic and health impact have prompted the development of tissue engineering approaches. Several natural and synthetic biodegradable polymers as well as composites, blends and hybrids based on such materials have been used to produce tendon and ligament scaffolds. Given the complex structure of native tissues, the production of fiber-based scaffolds has been the preferred option for tendon/ligament tissue engineering. Electrospinning and several textile methods such as twisting, braiding and knitting have been used to produce these scaffolds. This review focuses on the developments achieved in the preparation of tendon/ligament scaffolds based on different biodegradable polymers. Several examples are overviewed and their processing methodologies, as well as their biological and mechanical performances, are discussed.
韧带和肌腱是纤维组织，血管较少，再生能力有限。目前，韧带/肌腱损伤通常需要使用自体或同种异体移植物进行手术，但这会带来一些限制。这些不足加上巨大的经济和健康影响，促使人们开发了组织工程方法。已经使用了几种天然和合成可生物降解聚合物以及基于这些材料的复合材料、共混物和混合物，来生产肌腱和韧带支架。鉴于天然组织的复杂结构，基于纤维的支架的生产已成为肌腱/韧带组织工程的首选方案。静电纺丝和几种纺织方法，如扭转、编织和针织，已被用于生产这些支架。本综述重点介绍了基于不同可生物降解聚合物的肌腱/韧带支架的制备进展。综述了几个实例，并讨论了它们的加工方法以及它们的生物和机械性能。
