Product Review Branch, Division of Emerging & Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, US Food & Drug Administration, Silver Spring, Maryland, USA.
Transfusion. 2020 Jul;60(7):1624-1632. doi: 10.1111/trf.15752. Epub 2020 Mar 24.
Tick-borne agents of disease continue to emerge and subsequently expand their geographic distribution. The threat to blood safety by tick-borne agents is ever increasing and requires constant surveillance concomitant with implementation of appropriate intervention methods. In April 2017, the Food and Drug Administration organized a public workshop on emerging tick-borne pathogens (excluding Babesia microti and Lyme disease) designed to provide updates on the current understanding of emerging tick-borne diseases, thereby allowing for extended discussions to determine if decisions regarding mitigation strategies need to be made proactively. Subject matter experts and other stakeholders participated in this workshop to discuss issues of biology, epidemiology, and clinical burden of tick-borne agents, risk of transfusion-transmission, surveillance, and considerations for decision making in implementing safety interventions. Herein, we summarize the scientific presentations, panel discussions, and considerations going forward.
虫媒传染病病原体不断出现,并随之扩大其地理分布范围。虫媒传染病病原体对血液安全的威胁日益增加,这需要不断监测,并同时采取适当的干预措施。2017 年 4 月,美国食品药品监督管理局组织了一次关于新兴虫媒病原体(不包括微小巴贝斯虫和莱姆病)的公开研讨会,旨在提供对新兴虫媒传染病当前认识的最新信息,以便进行更广泛的讨论,以确定是否需要提前制定缓解策略的决策。主题专家和其他利益相关者参加了此次研讨会,讨论了虫媒传染病病原体的生物学、流行病学和临床负担、输血传播风险、监测以及实施安全干预措施的决策考虑因素。在此,我们总结了科学报告、小组讨论和未来的考虑因素。