Center for Protein Diagnostics, Ruhr University Bochum, Gesundheitscampus 4, 44801 Bochum, Germany.
J Med Chem. 2020 Apr 9;63(7):3472-3474. doi: 10.1021/acs.jmedchem.0c00392. Epub 2020 Mar 25.
A new application of stimulated Raman scattering (SRS) uses the benefit of a label-free molecular fingerprint to image the uptake and distribution of an alkyne-based drug in living cells. This method delivers information on cellular molecular composition and drug-cell interaction, showing the potential of SRS in drug development.
受激拉曼散射（SRS）的一种新应用利用了无标记分子指纹的优势，对活细胞中炔基药物的摄取和分布进行成像。该方法提供了关于细胞分子组成和药物-细胞相互作用的信息，显示了 SRS 在药物开发中的潜力。
