S-inova Biotech, Graduate Program in Biotechnology, Universidade Catolica Dom Bosco, Campo Grande, MS, Brazil.
Department of Genomic Sciences and Biotechnology, Center for Analysis of Proteomics and Biochemistry, Catholic University of Brasília, Brasília, DF, Brazil.
Curr Top Med Chem. 2020;20(14):1274-1290. doi: 10.2174/1568026620666200325112425.
Host defense peptides (HDPs) comprise a heterogeneous group of evolutionarily conserved and biologically active small molecules that are produced by different organisms. HDPs are widely researched because they often have multiple biological activities, for example antimicrobial, immunomodulatory and anticancer activity. In this context, in this review we focus on cryptic HDPs, molecules derived specifically from proteolytic processing of endogenous precursor proteins. Here, we explore the biological activity of such molecules and we further discuss the development of optimized sequences based on these natural cryptic HDPs. In addition, we present clinical-phase studies of cryptic HDPs (natural or optimized), and point out the possible applicability of these molecules in medicinal chemistry.
宿主防御肽（HDPs）是一组由不同生物体产生的具有进化保守性和生物活性的小分子的异质群体。由于 HDPs 通常具有多种生物学活性，例如抗菌、免疫调节和抗癌活性，因此它们受到广泛的研究。在这种情况下，在本次综述中，我们专注于隐匿性 HDPs，即源自内源性前体蛋白的蛋白水解加工的特定分子。在这里，我们探讨了此类分子的生物学活性，并进一步讨论了基于这些天然隐匿性 HDPs 的优化序列的开发。此外，我们还介绍了隐匿性 HDPs（天然或优化）的临床阶段研究，并指出这些分子在药物化学中的可能适用性。
