Center for Protein Studies, Faculty of Biology, Havana University, Cuba.
Core Facility Functional Peptidomics (CFP), Ulm University Medical Center, Ulm, Germany.
Peptides. 2021 Dec;146:170644. doi: 10.1016/j.peptides.2021.170644. Epub 2021 Aug 28.
Host defense peptides (HDPs) exhibit a broad range of antimicrobial and immunomodulatory activities. In this sense, both functions are like different sides of the same coin. The direct antimicrobial side was discovered first, and widely studied for the development of anti-infective therapies. In contrast, the immunomodulatory side was recognized later and in the last 20 years the interest in this field has been continuously growing. Different to their antimicrobial activities, the immunomodulatory activities of host defense peptides are more effective in vivo. They offer a great opportunity for new therapeutic applications in the fields of anti-infective therapy, chronic inflammatory diseases treatment, novel vaccine adjuvants development and anticancer immunotherapy. These immune related functions of HDPs includes chemoattraction of leukocytes, modulation of inflammation, enhancement of antigen presentation and polarization of adaptive immune responses. Our attempt with this review is to make a careful evaluation of different aspects of the less explored, but attractive immunomodulatory side of the HDP functional coin.
宿主防御肽（HDPs）具有广泛的抗菌和免疫调节活性。从这个意义上说，这两种功能就像同一枚硬币的两面。直接的抗菌作用首先被发现，并被广泛研究用于开发抗感染疗法。相比之下，免疫调节作用后来才被认识到，在过去的 20 年中，人们对这一领域的兴趣一直在不断增长。与它们的抗菌活性不同，宿主防御肽的免疫调节活性在体内更有效。它们为抗感染治疗、慢性炎症性疾病治疗、新型疫苗佐剂开发和癌症免疫治疗等领域的新的治疗应用提供了巨大的机会。宿主防御肽的这些免疫相关功能包括白细胞的趋化作用、炎症的调节、抗原呈递的增强和适应性免疫反应的极化。我们试图通过这篇综述，对宿主防御肽功能这枚硬币中不太被探索但具有吸引力的免疫调节方面进行仔细评估。
