Campus Benjamin Franklin, Department of Nephrology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universtität zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12203 Berlin, Germany.
Department of Chemistry, Biochemistry and Pharmacy, Freie Universität Berlin, Königin-Luise-Straβe 2+4, 14195 Berlin, Germany.
Int J Mol Sci. 2020 Mar 23;21(6):2204. doi: 10.3390/ijms21062204.
Calcification of the vessel wall contributes to high cardiovascular morbidity and mortality. Vascular calcification (VC) is a systemic disease with multifaceted contributing and inhibiting factors in an actively regulated process. The exact underlying mechanisms are not fully elucidated and reliable treatment options are lacking. Due to the complex pathophysiology, various research models exist evaluating different aspects of VC. This review aims to give an overview of the cell and animal models used so far to study the molecular processes of VC. Here, in vitro cell culture models of different origins, ex vivo settings using aortic tissue and various in vivo disease-induced animal models are summarized. They reflect different aspects and depict the (patho)physiologic mechanisms within the VC process.
血管壁钙化是导致心血管高发病率和高死亡率的原因之一。血管钙化（VC）是一种全身性疾病，在一个受积极调控的过程中有多种促成和抑制因素。确切的潜在机制尚未完全阐明，可靠的治疗方法也缺乏。由于病理生理学的复杂性，目前存在各种研究模型，用于评估 VC 的不同方面。本文旨在概述迄今为止用于研究 VC 分子过程的细胞和动物模型。这里总结了不同来源的体外细胞培养模型、使用主动脉组织的离体模型以及各种诱导疾病的体内动物模型，它们反映了 VC 过程中的不同方面，并描绘了（病理）生理机制。
