Krestinina Olga, Baburina Yulia, Krestinin Roman, Odinokova Irina, Fadeeva Irina, Sotnikova Linda
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow region, Russia.
Antioxidants (Basel). 2020 Mar 23;9(3):262. doi: 10.3390/antiox9030262.
Mitochondria are considered to be a power station of the cell. It is known that they play a major role in both normal and pathological heart function. Alterations in mitochondrial bioenergetics are one of the main causes of the origin and progression of heart failure since they have an inhibitory effect on the activity of respiratory complexes in the inner mitochondrial membrane. Astaxanthin (AST) is a xanthophyll carotenoid of mainly marine origin. It has both lipophilic and hydrophilic properties and may prevent mitochondrial dysfunction by permeating the cell membrane and co-localizing within mitochondria. The carotenoid suppresses oxidative stress-induced mitochondrial dysfunction and the development of diseases. In the present study, it was found that the preliminary oral administration of AST upregulated the activity of respiratory chain complexes and ATP synthase and the level of their main subunits, thereby improving the respiration of rat heart mitochondria (RHM) in the heart injured by isoproterenol (ISO). AST decreased the level of cyclophilin D (CyP-D) and increased the level of adenine nucleotide translocase (ANT) in this condition. It was concluded that AST could be considered as a potential mitochondrial-targeted agent in the therapy of pathological conditions associated with oxidative damage and mitochondrial dysfunction. AST, as a dietary supplement, has a potential in the prevention of cardiovascular diseases.
线粒体被认为是细胞的发电站。众所周知，它们在正常和病理性心脏功能中都起着重要作用。线粒体生物能量学的改变是心力衰竭发生和发展的主要原因之一，因为它们会抑制线粒体内膜呼吸复合体的活性。虾青素（AST）是一种主要来源于海洋的叶黄素类胡萝卜素。它兼具亲脂性和亲水性，可通过穿透细胞膜并在线粒体内共同定位来预防线粒体功能障碍。这种类胡萝卜素可抑制氧化应激诱导的线粒体功能障碍和疾病发展。在本研究中，发现预先口服AST可上调呼吸链复合体和ATP合酶的活性及其主要亚基的水平，从而改善异丙肾上腺素（ISO）损伤心脏中大鼠心脏线粒体（RHM）的呼吸功能。在此条件下，AST降低了亲环蛋白D（CyP-D）的水平并提高了腺嘌呤核苷酸转位酶（ANT）的水平。得出的结论是，AST可被视为治疗与氧化损伤和线粒体功能障碍相关的病理状况的潜在线粒体靶向药物。AST作为一种膳食补充剂，在预防心血管疾病方面具有潜力。
