Krestinina Olga, Odinokova Irina, Sotnikova Linda, Krestinin Roman, Zvyagina Alena, Baburina Yulia
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino 142290, Moscow Region, Russia.
Antioxidants (Basel). 2022 Oct 12;11(10):2019. doi: 10.3390/antiox11102019.
The search for new targets for the pathological action of ethanol remains an urgent task of biomedicine. Since degenerative changes in the liver are associated with the development of oxidative stress, antioxidants are promising agents for the treatment of alcohol-related diseases. In this work, we studied the ability of the carotenoid antioxidant, astaxanthin (AX), to prevent ethanol-induced changes in the liver of rats. It was shown that AX is able to protect the structure of mitochondria from degenerative changes caused by ethanol to improve mitochondrial functions. AX positively influences the activity and expression of proteins of the mitochondrial respiratory chain complexes and ATPase. In addition, a protective effect of AX on the rate and activity of mitochondrial respiration was demonstrated in the work. Thus, studies have shown that AX is involved in protective mechanisms in response to ethanol-induced mitochondrial dysfunction.
寻找乙醇病理作用的新靶点仍然是生物医学的一项紧迫任务。由于肝脏中的退行性变化与氧化应激的发展有关，抗氧化剂是治疗酒精相关疾病的有前景的药物。在这项工作中，我们研究了类胡萝卜素抗氧化剂虾青素（AX）预防乙醇诱导的大鼠肝脏变化的能力。结果表明，AX能够保护线粒体结构免受乙醇引起的退行性变化，从而改善线粒体功能。AX对线粒体呼吸链复合物和ATP酶的蛋白质活性和表达有积极影响。此外，该研究还证明了AX对线粒体呼吸速率和活性具有保护作用。因此，研究表明AX参与了对乙醇诱导的线粒体功能障碍的保护机制。
