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药用植物的分子视角与抗癌活性

Molecular perspective and anticancer activity of medicinal plants.

作者信息

Ahamed Anis, Panneerselvam A, Alaklabi Abdullah, Arif Ibrahim A, Ambikapathy V, Thajuddin N

机构信息

Prince Sultan Research Chair for Environment and Wildlife, Department of Botany and Microbiology, College of Sciences, King Saud University (KSU), Riyadh, Saudi Arabia.

Department of Botany and Microbiology, A.V.V.M. Sri Pushpam College (Autonomous), Poondi, Affiliated to Bharathidasan University, Thanjavur, India.

出版信息

Saudi J Biol Sci. 2020 Feb;27(2):666-675. doi: 10.1016/j.sjbs.2019.11.043. Epub 2019 Dec 17.

DOI:10.1016/j.sjbs.2019.11.043
PMID:32210686
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6997859/
Abstract

To evaluate phytochemical constituents from the methanolic extracts of medicinal plants and . The cytotoxic activity of and leaf extracts against Human colon cancer cell line (HCT-116) was also assessed. The two medicinal plant extracts having significant cytotoxic activity, meanwhile the methanolic extract of shows higher cytotoxic activity than extract. The shows remarkable activity against respective cell line than control. The characteristic chemical constituents of and leaf extracts were recognized from Gas chromatography and Mass spectrometry (GC-MS) technique. The molecular docking studies also support the cytotoxic activity.

摘要

评估药用植物甲醇提取物中的植物化学成分。同时还评估了[植物名称1]和[植物名称2]叶提取物对人结肠癌细胞系（HCT - 116）的细胞毒性活性。两种药用植物提取物具有显著的细胞毒性活性，同时[植物名称1]的甲醇提取物显示出比[植物名称2]提取物更高的细胞毒性活性。[植物名称1]对相应细胞系的活性比对照显著。通过气相色谱和质谱（GC - MS）技术鉴定了[植物名称1]和[植物名称2]叶提取物的特征化学成分。分子对接研究也支持细胞毒性活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/600ee41a4b49/gr12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/0209cf383c4b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/5625e19b0919/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/eff25af9e1d0/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/5a9d7fd9ba10/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/1a21dd513892/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/8ca5f256dabc/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/55f8892b6781/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/242a880e56f1/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/ad160471ef8e/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/145a2047420a/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/5f01859767e9/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/600ee41a4b49/gr12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/0209cf383c4b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/5625e19b0919/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/eff25af9e1d0/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/5a9d7fd9ba10/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/1a21dd513892/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/8ca5f256dabc/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/55f8892b6781/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/242a880e56f1/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/ad160471ef8e/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/145a2047420a/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/5f01859767e9/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff31/6997859/600ee41a4b49/gr12.jpg

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