Biology Department, Faculty of Science and Arts-Qilwah, Albaha University (BU), Al Bahah, Qilwah, Saudi Arabia.
Chemistry Department, Faculty of Science and Arts-Qilwah, Albaha University (BU), Al Bahah, Qilwah, Saudi Arabia.
J Gastrointest Cancer. 2023 Mar;54(1):51-55. doi: 10.1007/s12029-021-00793-w. Epub 2022 Jan 5.
Gastrointestinal cancers are the most dangerous cancers all over the world. The gut microbiota dysbiosis increases the risk of GI cancers and induces the host's susceptibility to carcinogenic bacteria. Antibiotic resistance is rising in these bacteria. Thus, discovering new safe and effective antibacterial agents is a worldwide concern. This study evaluates the antibacterial activity of six wild medicinal plants from the Al Bahah region in Saudi Arabia.
Arial parts of Cissus quadrangularis, Aloe castellorum, Psiadia punctulata, Aloe pseudorubroviolacea, Barbeya oleoides, Teucrium yemense were collected and dried for extraction with ethanol. The minimum inhibitory concentrations (MIC) of these ethanolic extracts against carcinogenic bacteria Bacteroides fragilis, Clostridium ssp., Cutibacterium acnes, Escherichia coli, Fusobacterium nucleatum, Helicobacter pylori, Mycoplasma spp., Neisseria gonorrhoeae, Porphyromonas gingivalis, Salmonella enterica, and Treponema pallidum were evaluated to determine its antibacterial activity.
All extracts showed antibacterial activity with MIC lower than 1 mg/ml. Psiadia punctulata showed higher antibacterial activity, while the Aloe species showed the lowest antibacterial activity.
The studied plants' extracts showed high effectiveness as antibacterial activity against the carcinogenic bacteria related to gastrointestinal cancers due to their high content of pharmaceutical components. These plants could be explored further for the development of new antibacterial products against these carcinogenic bacteria.
胃肠道癌症是全世界最危险的癌症。肠道微生物失调会增加胃肠道癌症的风险，并使宿主易受致癌细菌的影响。这些细菌的抗生素耐药性正在上升。因此，发现新的安全有效的抗菌剂是全世界关注的问题。本研究评估了来自沙特阿拉伯 Al Bahah 地区的六种野生药用植物的抗菌活性。
收集并干燥 Cissus quadrangularis、Aloe castellorum、Psiadia punctulata、Aloe pseudorubroviolacea、Barbeya oleoides 和 Teucrium yemense 的叶部分，并用乙醇进行提取。评估这些乙醇提取物对致癌细菌脆弱拟杆菌、梭状芽孢杆菌、痤疮丙酸杆菌、大肠杆菌、核梭杆菌、幽门螺杆菌、支原体、淋病奈瑟菌、牙龈卟啉单胞菌、沙门氏菌和梅毒螺旋体的最低抑菌浓度（MIC），以确定其抗菌活性。
所有提取物均表现出抗菌活性，MIC 低于 1mg/ml。Psiadia punctulata 表现出更高的抗菌活性，而 Aloe 种则表现出最低的抗菌活性。
由于这些植物含有丰富的药用成分，其提取物对与胃肠道癌症相关的致癌细菌具有很高的抗菌活性。这些植物可以进一步探索，以开发针对这些致癌细菌的新型抗菌产品。
