a Department of General Surgery , Qilu Hospital of Shandong University , Jinan , Shandong Province , China.
b Department of Ultrasound and Radiology , Shandong Provincial Hospital Affiliated to Shandong University , Jinan , Shandong Province , China.
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1617-1627. doi: 10.1080/21691401.2019.1594862.
Nanotechnology has been materialized as a proficient technology for the development of anticancer nanoparticles all the way through an environment-friendly approach. Conventionally, nanoparticles have been assembled by dissimilar methods, but regrettably rely on the negative impact on the natural environment. Amalgamation of nanoparticles by means of plant extract is alternate conservative methods. Scutellaria barbata species was used majorly as food or as medicines against various diseases, and extensive research was conducted for their therapeutic properties. The present research was mainly focused on the synthesis of gold nanoparticles from the Scutellaria barbata by green route method and evaluation of its anticancer activity against pancreatic cancer cell lines (PANC-1). The gold nanoparticles have been characterized by UV-visible spectroscopy, TEM, SAED, AFM, and FTIR analysis. The synthesized gold nanoparticles (AuNPs) possessed effective anticancer activity against pancreatic cancer cell lines (PANC-1). Hence, further research on this plant may lead to the development of novel anticancer drugs which can be used to combat pancreatic cancer.
纳米技术已成为一种通过环保方法开发抗癌纳米粒子的有效技术。传统上，纳米粒子是通过不同的方法组装的，但遗憾的是，这些方法会对自然环境产生负面影响。通过植物提取物来结合纳米粒子是另一种保守的方法。半枝莲是一种主要用作食品或治疗各种疾病的药物，人们对其治疗特性进行了广泛的研究。本研究主要集中在通过绿色路线方法从半枝莲中合成金纳米粒子，并评估其对胰腺癌细胞系（PANC-1）的抗癌活性。通过紫外-可见光谱、TEM、SAED、AFM 和 FTIR 分析对金纳米粒子进行了表征。合成的金纳米粒子（AuNPs）对胰腺癌细胞系（PANC-1）具有有效的抗癌活性。因此，对这种植物的进一步研究可能会开发出新型的抗癌药物，用于治疗胰腺癌。
