Zhang Yinghui, Ren Lemeng, Zheng Fengjie, Zhuang Xianghua, Jiang Dongqing, Chen Shihong, Ni Yihong, Li Xiaobo
Medical record room, The Second Hospital of Shandong University, 247 BeiYuan Road, JiNan, ShanDong, China.
The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China.
J Int Med Res. 2020 Mar;48(3):300060519897483. doi: 10.1177/0300060519897483.
To evaluate skeletal muscle mass in patients with both type 2 diabetes mellitus (T2DM) and concomitant lower extremity arterial disease (LEAD) and determine the contribution of skeletal muscle mass to macrovascular diseases.
In total, 112 patients with T2DM were divided into the T2DM and T2DM + LEAD groups. Hepatic function, renal function, uric acid, blood glucose, and glycated hemoglobin (HbA1C) were measured. Dual-energy X-ray absorptiometry was used to measure visceral fat area and skeletal muscle mass index (SMI).
Waist-to-hip ratio, uric acid, and body fat percentage were significantly higher in the T2DM+LEAD group than in the T2DM group; SMI was significantly lower in the T2DM+LEAD group than in the T2DM group. There were no significant differences in albumin, creatinine, fasting blood glucose, HbA1C, or blood lipids. Uric acid, SMI, and body fat percentage were significantly positively correlated with T2DM and concomitant LEAD. Logistic regression analyses suggested that SMI is an independent risk factor for LEAD in T2DM (odds ratio = 1.517; 95% confidence interval: 1.082–2.126).
Skeletal muscle mass is lower in patients with T2DM and concomitant LEAD than in patients with T2DM who do not exhibit LEAD. SMI is an important risk factor for LEAD.
评估2型糖尿病（T2DM）合并下肢动脉疾病（LEAD）患者的骨骼肌质量，并确定骨骼肌质量对大血管疾病的影响。
总共112例T2DM患者被分为T2DM组和T2DM + LEAD组。检测肝功能、肾功能、尿酸、血糖和糖化血红蛋白（HbA1C）。采用双能X线吸收法测量内脏脂肪面积和骨骼肌质量指数（SMI）。
T2DM + LEAD组的腰臀比、尿酸和体脂百分比显著高于T2DM组；T2DM + LEAD组的SMI显著低于T2DM组。白蛋白、肌酐、空腹血糖、HbA1C或血脂无显著差异。尿酸、SMI和体脂百分比与T2DM及合并的LEAD显著正相关。Logistic回归分析表明，SMI是T2DM患者发生LEAD的独立危险因素（比值比 = 1.517；95%置信区间：1.082 - 2.126）。
T2DM合并LEAD患者的骨骼肌质量低于未出现LEAD的T2DM患者。SMI是LEAD的重要危险因素。
