Veterans Affairs Medical Center Baltimore, Geriatric Research Education and Clinical Center (GRECC), Baltimore, MD; Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore, MD.
Veterans Affairs Medical Center Baltimore, Geriatric Research Education and Clinical Center (GRECC), Baltimore, MD; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.
Arch Phys Med Rehabil. 2018 Apr;99(4):623-628. doi: 10.1016/j.apmr.2017.10.017. Epub 2017 Nov 11.
(1) To determine the prevalence of sarcopenia in older men with peripheral arterial disease (PAD); (2) to compare a subgroup of the group with age-, race-, sex-, and body mass index (BMI)-matched non-PAD control counterparts, and (3) to compare the functional status of those with PAD with and without sarcopenia.
Cohort study.
Medical center.
Sedentary community-dwelling men (N=108; age, >50y) with a confirmed diagnosis of PAD (44% blacks; BMI, 27.8±0.4kg/m; ankle-brachial index, .62±.01).
Not applicable.
Dual-energy x-ray absorptiometry scans were used to assess appendicular lean mass and determine the prevalence of sarcopenia by/height. Treadmill tests were used to determine claudication onset time, peak walking time, and claudication recovery time. 6-Minute walk distance was also measured.
Sarcopenia prevalence in our PAD cohort was 25%. The PAD subgroup (n=42) matched with control counterparts in terms of race, sex, age, and BMI had higher prevalence rates than did their non-PAD counterparts (23.8% vs 2.4%; P<.05). Individuals with sarcopenia (n=28) had a shorter 6-minute walk distance (326±18.8m vs 380±9.7m; P<.05) and higher claudication recovery time (592±98s vs 395±29s; P<.05) than did individuals with PAD but without sarcopenia (n=80). There was no difference in claudication onset time or peak walking time between the PAD groups.
Men with PAD demonstrate a high prevalence of sarcopenia. Those with sarcopenia and PAD demonstrate decreased mobility function.
（1）确定患有外周动脉疾病（PAD）的老年男性中肌少症的患病率；（2）与年龄、种族、性别和体重指数（BMI）匹配的非 PAD 对照组亚组进行比较；（3）比较患有 PAD 伴或不伴肌少症患者的功能状态。
队列研究。
医疗中心。
久坐的社区居住男性（N=108；年龄>50 岁），确诊患有 PAD（44%为黑人；BMI，27.8±0.4kg/m；踝肱指数，0.62±0.01）。
无。
使用双能 X 射线吸收法扫描来评估四肢瘦组织质量，并根据身高确定肌少症的患病率。跑步机测试用于确定跛行起始时间、最大步行时间和跛行恢复时间。还测量了 6 分钟步行距离。
我们的 PAD 队列中肌少症的患病率为 25%。PAD 亚组（n=42）与对照组在种族、性别、年龄和 BMI 方面相匹配，其患病率高于非 PAD 对照组（23.8%比 2.4%；P<.05）。患有肌少症的个体（n=28）的 6 分钟步行距离更短（326±18.8m 比 380±9.7m；P<.05），跛行恢复时间更长（592±98s 比 395±29s；P<.05），而非 PAD 但无肌少症的个体（n=80）。PAD 组之间的跛行起始时间或最大步行时间没有差异。
患有 PAD 的男性肌少症患病率较高。患有肌少症和 PAD 的患者移动功能下降。
