Tsugawa Akito, Ogawa Yusuke, Takenoshita Naoto, Kaneko Yoshitsugu, Hatanaka Hirokuni, Jaime Eriko, Fukasawa Raita, Hanyu Haruo
Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
Dement Geriatr Cogn Dis Extra. 2017 Dec 22;7(3):454-462. doi: 10.1159/000485177. eCollection 2017 Sep-Dec.
BACKGROUND/AIMS: Diabetes-related dementia (DrD), a dementia subgroup associated with specific diabetes mellitus (DM)-related metabolic abnormalities, is clinically and pathophysiologically different from Alzheimer disease (AD) and vascular dementia. We determined whether skeletal muscle strength, quality, and mass decrease in individuals with DrD.
We evaluated grip and knee extension strength, muscle mass, and gait speed in 106 patients with probable AD and without type 2 DM (AD[-DM] group), 74 patients with probable AD and with DM (AD[+DM] group), and 36 patients with DrD (DrD group). Muscle quality was defined as the ratio of muscle strength to muscle mass.
Both female and male subjects with DrD showed significantly decreased muscle strength and quality in the upper extremities compared with the subjects with AD[-DM] or AD[+DM]. Female subjects with DrD showed significantly decreased muscle quality in the lower extremities compared with the subjects with AD[-DM]. Both female and male subjects with DrD had a significantly lower gait speed compared with the subjects with AD[-DM]. However, there were no significant differences in muscle mass and the prevalence of sarcopenia between the groups.
Subjects with DrD showed decreased muscle strength and quality, but not muscle mass, and had a low gait speed.
背景/目的：糖尿病相关痴呆（DrD）是一种与特定糖尿病（DM）相关代谢异常相关的痴呆亚组，在临床和病理生理上与阿尔茨海默病（AD）和血管性痴呆不同。我们确定了DrD患者的骨骼肌力量、质量和质量是否下降。
我们评估了106例可能患有AD且无2型糖尿病的患者（AD[-DM]组）、74例可能患有AD且患有DM的患者（AD[+DM]组）和36例患有DrD的患者（DrD组）的握力和膝关节伸展力量、肌肉质量和步态速度。肌肉质量定义为肌肉力量与肌肉质量的比值。
与AD[-DM]或AD[+DM]组的受试者相比，患有DrD的女性和男性受试者上肢的肌肉力量和质量均显著下降。与AD[-DM]组的受试者相比，患有DrD的女性受试者下肢的肌肉质量显著下降。与AD[-DM]组的受试者相比，患有DrD的女性和男性受试者的步态速度均显著降低。然而，各组之间的肌肉质量和肌肉减少症患病率没有显著差异。
患有DrD的受试者表现出肌肉力量和质量下降，但肌肉质量未下降，且步态速度较低。
