Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil.
Laboratório de Neuroquímica, Inflamação e Câncer, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil.
Arch Physiol Biochem. 2022 Aug;128(4):993-1000. doi: 10.1080/13813455.2020.1743723. Epub 2020 Mar 26.
In this study, we evaluated the effects of native fruit extracts on inflammatory and thromboregulatory parameters in animal model of metabolic syndrome (MetS) induced by highly palatable diet (HPD). Rats were divided into 4 experimental groups: standard chow, HPD, HPD and extract, and HPD and extract. HPD increased serum interleukin-6 (IL-6) levels. On the other hand, this change was prevented by extracts. HPD decreased NTPDase activity in lymphocytes and platelets and 5'-nucleotidase in platelets. Treatment with extracts prevented these changes. An increase in adenosine deaminase (ADA) activity was prevented by in lymphocytes and serum of rats. Fruit extracts prevented the increase in the activity of acetylcholinesterase (AChE) in lymphocytes and butyrylcholinesterase (BuChE) in serum induced by the HPD. Brazilian native fruit extracts have anti-inflammatory and antithrombotic effects, demonstrating therapeutic potential in the prevention of complications associated with MetS.
在这项研究中，我们评估了天然水果提取物对高美味饮食（HPD）诱导的代谢综合征（MetS）动物模型中炎症和血栓调节参数的影响。大鼠被分为 4 个实验组：标准饲料、HPD、HPD 和 提取物、HPD 和 提取物。HPD 增加了血清白细胞介素-6（IL-6）水平。另一方面，这些变化被提取物所阻止。HPD 降低了淋巴细胞和血小板中的 NTPDase 活性以及血小板中的 5'-核苷酸酶。提取物的治疗预防了这些变化。在淋巴细胞和大鼠血清中， 阻止了腺苷脱氨酶（ADA）活性的增加。巴西天然水果提取物具有抗炎和抗血栓作用，显示出在预防与 MetS 相关的并发症方面的治疗潜力。
