Institute of Natural Fibres and Medicinal Plants, Wojska Polskiego 71b, 60-630 Poznan, Poland; Department of Pharmaceutical Botany and Plant Biotechnology, Poznan University of Medical Sciences, Sw. Marii Magdaleny 14, 61-861 Poznan, Poland.
Institute of Natural Fibres and Medicinal Plants, Wojska Polskiego 71b, 60-630 Poznan, Poland; Department of Pharmacology, Poznan University of Medical Sciences, Rokietnicka 5a, 60-806 Poznan, Poland.
Fitoterapia. 2013 Dec;91:261-271. doi: 10.1016/j.fitote.2013.09.012. Epub 2013 Sep 27.
Rosmarinus officinalis L. leaf as part of a diet and medication can be a valuable proposal for the prevention and treatment of dementia. The aim of the study was to assess the effects of subchronic (28-fold) administration of a plant extract (RE) (200 mg/kg, p.o.) on behavioral and cognitive responses of rats linked with acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activity and their mRNA expression level in the hippocampus and frontal cortex. The passive avoidance test results showed that RE improved long-term memory in scopolamine-induced rats. The extract inhibited the AChE activity and showed a stimulatory effect on BuChE in both parts of rat brain. Moreover, RE produced a lower mRNA BuChE expression in the cortex and simultaneously an increase in the hippocampus. The study suggests that RE led to improved long-term memory in rats, which can be partially explained by its inhibition of AChE activity in rat brain.
迷迭香叶片作为饮食和药物的一部分，可以成为预防和治疗痴呆的有价值的建议。本研究的目的是评估亚慢性（28 倍）给予植物提取物（RE）（200mg/kg，po）对与乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BuChE）活性相关的大鼠行为和认知反应的影响，以及其在海马体和前额叶皮质中的 mRNA 表达水平。被动回避测试结果表明，RE 改善了东莨菪碱诱导的大鼠的长期记忆。该提取物抑制了 AChE 活性，并在大鼠大脑的两个部位均对 BuChE 表现出刺激作用。此外，RE 使皮质中的 BuChE mRNA 表达降低，同时使海马体中的 BuChE mRNA 表达增加。该研究表明，RE 导致大鼠的长期记忆得到改善，这可以部分解释为其抑制了大鼠大脑中的 AChE 活性。
