Masugi F, Ogihara T, Hashizume K, Hasegawa T, Sakaguchi K, Kumahara Y
Department of Medicine and Geriatrics, Osaka University Medical School, Japan.
J Hum Hypertens. 1988 Mar;1(4):293-8.
The short-term effects of manipulating dietary salt intake on plasma levels of cholesterol, lipoproteins and uric acid were studied in two groups of patient with essential hypertension. With dietary salt restriction in 8 patients (10 g to 2 g salt/day for five days), plasma total cholesterol, esterified cholesterol, beta-lipoprotein, low density lipoprotein and uric acid rose significantly. With salt repletion (2 g salt/day to 20 g/day for five days) in 17 patients, plasma total cholesterol, esterified cholesterol, beta-lipoprotein, low density lipoprotein and uric acid fell significantly. Total/HDL cholesterol ratio increased significantly with salt restriction and decreased significantly with repletion. However, very low density lipoprotein, HDL-cholesterol, triglyceride, phospholipid, chylomicron and non-esterified fatty acid were not influenced by the changes in salt intake. These results indicate that the severe restriction of dietary salt raises plasma cholesterol and uric acid levels in patients with essential hypertension in the short term.
在两组原发性高血压患者中研究了控制饮食盐摄入量对血浆胆固醇、脂蛋白和尿酸水平的短期影响。8例患者进行饮食限盐（从每日10克盐减至每日2克盐，持续5天）后，血浆总胆固醇、酯化胆固醇、β-脂蛋白、低密度脂蛋白和尿酸显著升高。17例患者进行盐补充（从每日2克盐增至每日20克盐，持续5天）后，血浆总胆固醇、酯化胆固醇、β-脂蛋白、低密度脂蛋白和尿酸显著下降。总胆固醇/高密度脂蛋白胆固醇比值在限盐时显著升高，在盐补充时显著降低。然而，极低密度脂蛋白、高密度脂蛋白胆固醇、甘油三酯、磷脂、乳糜微粒和非酯化脂肪酸不受盐摄入量变化的影响。这些结果表明，短期内严格限制饮食盐会使原发性高血压患者的血浆胆固醇和尿酸水平升高。
