Baltina L A, Kondratenko R M, Baltina L A, Plyasunova O A, Pokrovskii A G, Tolstikov G A
1Institute of Organic Chemistry, UfaScientific Center, Russian Academy of Sciences, Ufa, Bashkortostan Russia.
2Bashkir State Medical University, Ufa, Bashkortostan Russia.
Pharm Chem J. 2009;43(10):539-548. doi: 10.1007/s11094-010-0348-2. Epub 2010 Feb 4.
The review is devoted to the problem of creating new antiviral drugs based on glycyrrhizic acid (GA), the major triterpene glycoside extracted from roots of common and Ural licorice ( L. and Fisher, respectively). Published data on the natural GA sources, antiviral activity of GA and its derivatives, clinical applications of GA-based drugs, and the properties of GA-containing biologically active nutrient additives are summarized. Possible mechanisms of the antiviral activity of GA and its derivatives are examined. It is shown that chemical modification of GA is a promising way of designing new highly active antiviral drugs for the prophylaxis and treatment of HIV, hepatitis B and C, corona-virus, and herpes simplex virus infections.
这篇综述致力于基于甘草酸（GA）开发新型抗病毒药物的问题，甘草酸是从普通甘草和乌拉尔甘草（分别为甘草和光果甘草）根部提取的主要三萜糖苷。总结了关于天然GA来源、GA及其衍生物的抗病毒活性、GA类药物的临床应用以及含GA的生物活性营养添加剂特性的已发表数据。研究了GA及其衍生物抗病毒活性的可能机制。结果表明，GA的化学修饰是设计用于预防和治疗HIV、乙型和丙型肝炎、冠状病毒以及单纯疱疹病毒感染的新型高活性抗病毒药物的一种有前景的方法。
