Gómez-Verjan J, Gonzalez-Sanchez I, Estrella-Parra E, Reyes-Chilpa R
Departamento de Productos Naturales, Instituto de Química, Universidad Nacional Autónoma de México, 04510 Mexico City, Distrito Federal Mexico.
Scientometrics. 2015;105(2):1019-1030. doi: 10.1007/s11192-015-1715-2. Epub 2015 Sep 2.
Tropical trees of genus (Calophyllaceae) have chemical and biological importance as potential source of secondary active metabolites which can lead to the development of new drugs. Research on this species has been rising since 1992 due to the discovering of anti-HIV properties of Calanolide A found in leaves. This compound is the most important natural product for potential development of new anti-HIV drugs and phytomedicines. The scientometric analysis (1953-2014) here performed revealed that the most studied species of genus are: and , distributed in the Asian, and American continents, respectively. Current research on these species is carried out mainly in India and Brazil, respectively, where these species grow. Research on is focused mainly on ecological, antiparasitic, cytotoxic properties, and isolation of new compounds. Chemical studies and biodiesel development are the main topics in the case of . Text mining analysis revealed that coumarins, and xanthones are the main secondary active metabolites responsible for most of the reported pharmacological properties, and are potential compounds for the treatment of leukemia and against intracellular parasites causing American Trypanosomiasis and Leshmaniasis. On the other hand, represents an important source for the development of 2nd generation biodiesel. Medicinal and industrial applications of these species may impulse sustainable forest plantations. To our knowledge this is the first scientometric and text mining analysis of chemical and biomedical research on genus, and .
红厚壳属（金丝桃科）的热带树木具有化学和生物学重要性，作为次生活性代谢物的潜在来源，可能会促成新药的研发。自1992年以来，由于在其叶子中发现了卡诺醇内酯A的抗HIV特性，对该物种的研究不断增加。这种化合物是新抗HIV药物和植物药潜在开发中最重要的天然产物。此处进行的科学计量分析（1953 - 2014年）表明，红厚壳属中研究最多的物种分别是：亚洲的红厚壳和美洲的红厚壳。目前对这些物种的研究分别主要在它们生长的印度和巴西进行。对红厚壳的研究主要集中在生态、抗寄生虫、细胞毒性特性以及新化合物的分离上。对于红厚壳，化学研究和生物柴油开发是主要课题。文本挖掘分析表明，香豆素和呫吨酮是导致大多数已报道药理特性的主要次生活性代谢物，是治疗白血病以及对抗导致美洲锥虫病和利什曼病的细胞内寄生虫的潜在化合物。另一方面，红厚壳是第二代生物柴油开发的重要来源。这些物种的药用和工业应用可能会推动可持续人工林的发展。据我们所知，这是对红厚壳属、红厚壳和红厚壳的化学与生物医学研究的首次科学计量和文本挖掘分析。
