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Chin Sci Bull. 2004;49(12):1311-1313. doi: 10.1360/04wc0153. Epub 2013 Aug 30.

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A complete sequence and comparative analysis of a SARS-associated virus (Isolate BJ01).一种与SARS相关病毒（分离株BJ01）的完整序列及比较分析。
Chin Sci Bull. 2003;48(10):941-948. doi: 10.1007/BF03184203.
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The Genome sequence of the SARS-associated coronavirus.与严重急性呼吸综合征相关的冠状病毒的基因组序列。
Science. 2003 May 30;300(5624):1399-404. doi: 10.1126/science.1085953. Epub 2003 May 1.
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Identification of a receptor-binding domain of the spike glycoprotein of human coronavirus HCoV-229E.人冠状病毒HCoV-229E刺突糖蛋白受体结合结构域的鉴定
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Mutational analysis of the virus and monoclonal antibody binding sites in MHVR, the cellular receptor of the murine coronavirus mouse hepatitis virus strain A59.鼠冠状病毒A59株的细胞受体MHVR中病毒和单克隆抗体结合位点的突变分析
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Identification of spike protein residues of murine coronavirus responsible for receptor-binding activity by use of soluble receptor-resistant mutants.利用可溶性受体抗性突变体鉴定鼠冠状病毒中负责受体结合活性的刺突蛋白残基。
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Virus-receptor interactions in the enteric tract. Virus-receptor interactions.肠道中的病毒-受体相互作用。病毒-受体相互作用。
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Localization of neutralizing epitopes and receptor-binding site in murine coronavirus spike protein.
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Analysis of the receptor-binding site of murine coronavirus spike protein.鼠冠状病毒刺突蛋白受体结合位点的分析
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Localization of neutralizing epitopes and the receptor-binding site within the amino-terminal 330 amino acids of the murine coronavirus spike protein.鼠冠状病毒刺突蛋白氨基末端330个氨基酸内中和表位及受体结合位点的定位
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与严重急性呼吸综合征相关病毒和鼠肝炎病毒之间的刺突蛋白同源性意味着存在一个假定的受体结合区域。

Spike protein homology between the SARS-associated virus and murine hepatitis virus implies existence of a putative receptor-binding region.

作者信息

Lu Yun, Chen Yinghua

机构信息

Laboratory of Immunology, Department of Biology, Tsinghua University, Protein Science Laboratory of Ministry of Education, 100084 Beijing, China.

出版信息

Chin Sci Bull. 2003;48(11):1115-1117. doi: 10.1007/BF03185764.

DOI:10.1007/BF03185764
PMID:32214699
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7089281/
Abstract

Coronavirus has been determined to be the cause of the recent outbreak of severe acute respiratory syndrome (SARS). Human coronavirus 229E had been studied well and its receptor-binding domain was restricted to aa417-547 of S protein. However, this region has no homology with the newly separated SARS-associated virus (Hong Kong isolate CUHK-W1). Then we analyzed the phylogenesis of S1 subunit of the coronavirus spike protein (SARS-associated virus, Hong Kong isolate CUHK-W1). Interestingly, the highest homology between murine hepatitis virus (MHV) and SARS-associated coronavirus was found. And the important sites (aa62-65 and aa214-216) on the spike protein of MHV with receptor-binding capacity were highly conservative in comparison with the newly separated SARS-associated virus (the corresponding sites are aa51-54 and aal95-197). These results from bioinformatics analysis might help us to study the receptor-binding sites of SARS-associated virus and the mechanism of the virus entry into the target cell, and design antiviral drugs and potent vaccines.

摘要

冠状病毒已被确定为近期严重急性呼吸综合征（SARS）爆发的病因。人冠状病毒229E已得到充分研究，其受体结合域局限于S蛋白的417-547氨基酸区域。然而，该区域与新分离出的SARS相关病毒（香港分离株CUHK-W1）没有同源性。然后我们分析了冠状病毒刺突蛋白S1亚基（SARS相关病毒，香港分离株CUHK-W1）的系统发生。有趣的是，发现鼠肝炎病毒（MHV）与SARS相关冠状病毒之间具有最高同源性。与新分离出的SARS相关病毒相比，MHV刺突蛋白上具有受体结合能力的重要位点（62-65氨基酸和214-216氨基酸）高度保守（相应位点为51-54氨基酸和195-197氨基酸）。这些生物信息学分析结果可能有助于我们研究SARS相关病毒的受体结合位点以及病毒进入靶细胞的机制，并设计抗病毒药物和有效的疫苗。