Holmes K V, Tresnan D B, Zelus B D
Department of Microbiology, University of Colorado Health Sciences Center, Denver 80262, USA.
Adv Exp Med Biol. 1997;412:125-33. doi: 10.1007/978-1-4899-1828-4_20.
Expression of specific virus receptors on the surface of intestinal epithelial cells or M cells can determine whether or not a animal is susceptible to infection with an enterotropic virus. Receptors for many animal viruses have been identified. The specificity of virus-receptor interactions clearly affects the species specificity of virus infection, and in some instances may be an important determinant of viral tissue tropism. In this paper, the specificity of coronavirus-receptor interactions is summarized. Porcine and human coronaviruses utilize aminopeptidase N as their receptors, but in a species-specific manner. Mouse hepatitis virus uses several rodent glycoproteins in the carcinoembryonic antigen family as receptors. In addition, some coronaviruses can interact with carbohydrate moieties on the cell surface. Understanding the molecular mechanisms of virus-receptor interactions may lead to development of novel strategies for the control of enteric viral diseases.
肠道上皮细胞或M细胞表面特定病毒受体的表达可决定动物是否易感染嗜肠性病毒。许多动物病毒的受体已被鉴定出来。病毒与受体相互作用的特异性明显影响病毒感染的物种特异性，在某些情况下可能是病毒组织嗜性的重要决定因素。本文总结了冠状病毒与受体相互作用的特异性。猪冠状病毒和人冠状病毒以物种特异性的方式利用氨肽酶N作为它们的受体。小鼠肝炎病毒使用癌胚抗原家族中的几种啮齿动物糖蛋白作为受体。此外，一些冠状病毒可与细胞表面的碳水化合物部分相互作用。了解病毒与受体相互作用的分子机制可能会带来控制肠道病毒性疾病的新策略。
