Kazakova O B, Medvedeva N I, Baikova I P, Tolstikov G A, Lopatina T V, Yunusov M S, Zaprutko L
1Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, 450054 Russia.
2Organic Chemistry Department, Poznan University of Medical Sciences, Poznan, Poland.
Russ J Bioorg Chem. 2010;36(6):771-778. doi: 10.1134/S1068162010060142. Epub 2010 Nov 19.
The synthesis of a new group of triterpenoid acylates has been conducted on the basis of oleanolic, glycyrrhetic, and ursolic acids and betulin. 28--Methoxycynnamoylbetulin has been demonstrated to possess high activity against the influenza type A (H1N1) virus with the selectivity index SI > 100 while studying the activity of the synthesized compounds in relation to the reproduction of viral pathogens of respiratory infections. The high activity of 3,28-dinicotinoylbetulin against the papilloma virus (strain HPV-11) was detected with the selectivity index SI 35.
基于齐墩果酸、甘草次酸、熊果酸和桦木醇合成了一组新的三萜酰化物。在研究合成化合物对呼吸道感染病毒病原体繁殖的活性时，已证明28 - 甲氧基肉桂酰桦木醇对甲型流感病毒（H1N1）具有高活性，选择性指数SI > 100。检测到3,28 - 二烟酰桦木醇对乳头瘤病毒（HPV - 11株）具有高活性，选择性指数SI为35。
