Han Huiming, Liu Wenhong, Cui Xinjie, Cheng Xu, Jiang Xiawei
Medical College, Beihua University, Jilin, People's Republic of China.
The Center for Infection and Immunity, Beihua University, Jilin, People's Republic of China.
Infect Drug Resist. 2020 Mar 16;13:851-854. doi: 10.2147/IDR.S245047. eCollection 2020.
The emergence of the plasmid-borne colistin-resistant gene () poses a great threat to human health. What is worse, the recent observations of the co-existence of with other antimicrobial resistance genes in some bacteria cause further concern. Here, we present the first report of a wild strain that co-carries an encoding phage-like IncY plasmid (pR15_MCR-1) and a encoding IncX3 plasmid (pR15_NDM-5) from a pharmaceutical industry, wastewater treatment plant, in China. This study highlights the spreading of carrying both and genes in the pharmaceutical industry.
strains that carry both and genes are of great health concern and are already found in humans and animals worldwide, yet there is a paucity of observations of this resistant strain in the environment. Here we present the first isolation of an strain (R15) that co-carries and genes from a wastewater treatment plant in China. Whole-genome sequencing indicated that R15 harbored two plasmids, pR15_MCR-1 and pR15_NDM-5, that carry and , respectively. The observation of this wild-derived strain that carries and genes simultaneously calls for the urgency to improve monitoring and reducing its further spreading.
质粒介导的耐黏菌素基因（）的出现对人类健康构成了巨大威胁。更糟糕的是，最近在一些细菌中观察到与其他抗菌抗性基因共存，这引起了进一步的关注。在此，我们首次报道了一株来自中国一家制药厂废水处理厂的野生菌株，它同时携带一个编码噬菌体样IncY质粒（pR15_MCR-1）的基因和一个编码IncX3质粒（pR15_NDM-5）的基因。本研究强调了在制药行业中携带和基因的传播情况。
携带和基因的菌株对健康构成重大威胁，并且在全球范围内的人类和动物中都已发现，但在环境中对这种耐药菌株的观察却很少。在此，我们首次从中国一家废水处理厂分离出一株同时携带和基因的菌株（R15）。全基因组测序表明，R15含有两个质粒，pR15_MCR-1和pR15_NDM-5，分别携带和基因。对这种同时携带和基因的野生来源菌株的观察表明，迫切需要加强监测并减少其进一步传播。
