蝎毒——有助于药物开发的毒素：综述

Ghosh Arijit, Roy Rini, Nandi Monoswini, Mukhopadhyay Ashis

1Department of Molecular Biology, Netaji Subhas Chandra Bose Cancer Research Institute, 16 A Park Lane, Kolkata, 700016 India.

2Department of Molecular Biology and Biotechnology, Kalyani University, University Road, Near Kalyani Ghoshpara Railway Station, District Nadia, Kalyani, West Bengal 741235 India.

Int J Pept Res Ther. 2019;25(1):27-37. doi: 10.1007/s10989-018-9721-x. Epub 2018 Jun 5.

Scorpion venom components have multifaceted orientation against bacterial, viral, fungal infections and other neuronal disorders. They can modulate the ion channels (K, Na, Cl, Ca) of our body and this concept has been hypothesized in formulating pharmaceuticals. The triumphant achievement of these venom components as formulated anticancer agent in Phase I and Phase II clinical trials allure researchers to excavate beneficial venom components prohibiting DNA replication in malignant tumor cells. This review brings forth the achievements of Science and Technology in classifying the venom components as therapeutics and further application in drug product development.

蝎子毒液成分在对抗细菌、病毒、真菌感染及其他神经紊乱方面具有多方面的作用。它们可以调节人体的离子通道（钾、钠、氯、钙），并且这一概念已被用于药物研发的假设中。这些毒液成分作为抗癌药物在一期和二期临床试验中取得的成功吸引了研究人员去挖掘能抑制恶性肿瘤细胞中DNA复制的有益毒液成分。这篇综述阐述了在将毒液成分分类为治疗剂以及在药品开发中的进一步应用方面的科技成果。