Ngoc Vo Truong Nhu, Coulton Kimberly Mathieu, Tra Nguyen Thu, My Nguyen Ha, Huong Phi Thi Quynh, Son Tong Minh, Anh Le Quynh, Thuy Luu Quang, Anh Tran Tuan, Dinh Thien Chu, Toi Chu Dinh
School of Odonto Stomatology, Hanoi Medical University, Hanoi, Vietnam.
School of Dentistry, Faculty of Medicine and Health, University of Sydney, Australia.
Open Access Maced J Med Sci. 2019 Dec 20;7(24):4319-4323. doi: 10.3889/oamjms.2019.383. eCollection 2019 Dec 30.
Fluoride therapy has long been used extensively to prevent dental caries. Fluoride appears in a variety of dental care products such as mouth rinses, dentifrices, gels, etc. HMU Fluorinze is the first mouthwash containing fluoride in Vietnam.
This research was conducted to evaluate the efficacy of HMU Fluorinze mouthwash on remineralizing enamel in laboratory conditions.
20 third molar teeth were cleaned and covered with nail polish, except for a 3 x 3 mm square on their buccal surfaces. These teeth underwent two steps: demineralization using Coca-cola and remineralization for 20 daysusing standard calcifying solution (control group) and standard calcifying solution + HMU Fluorinze mouthwash 2 times/day (experimental group). The index measured of enamel structure after demineralization and remineralization was assessed by a DIAGNOdent pen 2190.
The indices measured of the control group and experimental group at baseline were 3.65 ± 0.76 and 3.35 ± 0.64 respectively. After demineralization the control group measured 21.78 ± 4.48 and the experimental group, 20.25 ± 2.26. Following remineralization, the control group scores were 6.30 ± 1.03 and the experimental group, 3.90 ± 1.24, demonstrating statistical significance (p < 0.01) between the two groups. After 20 days, the results for the experimental group did not differ from the original results (p = 0.272), in contrast with the control group (p < 0.01).
Results show that HMU Fluorinze mouthwash is better at remineralizing than standard calcifying solution.
长期以来，氟化物疗法被广泛用于预防龋齿。氟化物存在于多种口腔护理产品中，如漱口水、牙膏、凝胶等。HMU Fluorinze是越南首款含氟漱口水。
本研究旨在评估HMU Fluorinze漱口水在实验室条件下对牙釉质再矿化的功效。
20颗第三磨牙经清洁后，除颊面3×3毫米见方的区域外均涂上指甲油。这些牙齿经过两个步骤：先用可口可乐进行脱矿，然后用标准钙化溶液（对照组）和标准钙化溶液+HMU Fluorinze漱口水每天两次（实验组）进行20天的再矿化。脱矿和再矿化后牙釉质结构的测量指标通过DIAGNOdent pen 2190进行评估。
对照组和实验组在基线时的测量指标分别为3.65±0.76和3.35±0.64。脱矿后，对照组为21.78±4.48，实验组为20.25±2.26。再矿化后，对照组评分为6.30±1.03，实验组为3.90±1.24，两组之间具有统计学意义（p<0.01）。20天后，实验组的结果与原始结果无差异（p = 0.272），而对照组则有差异（p<0.01）。
结果表明，HMU Fluorinze漱口水在再矿化方面比标准钙化溶液更好。
