Alhussain Abdulmajeed Mohammed, Alhaddad Abdulhakeem Ali, Ghazwi Mahdi Mohammed, Farooq Imran
Dental Intern, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Department of Biomedical Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Dent Med Probl. 2018 Oct-Dec;55(4):379-382. doi: 10.17219/dmp/97311.
Remineralization potential of dentifrices with novel compositions that can restore minerals back into incipient carious lesions has not been extensively studied so far.
The aim of this study was to assess the efficacy of a dentifrice based on novel fluoride incorporated bioactive glass in remineralizing artificial carious lesions in human enamel, and compare it with a standard fluoride-containing dentifrice.
Twenty-four human extracted teeth were sectioned at the cementoenamel junction to obtain enamel blocks. These blocks (n = 24) were randomly divided into 3 groups, with each group containing 8 specimens: group 1 (negative control group; distilled water), group 2 (positive control group; fluoride toothpaste) and group 3 (test group; BioMinTM F toothpaste). Artificial carious lesions were produced in the enamel surfaces by exposing them to a demineralization solution (6% citric acid, pH 2.2) for 96 h. After demineralization, the specimens were brushed with manual toothbrushes in a toothbrush simulation machine (each sample received 800 strokes). For brushing the specimens from group 1, 20 mL of distilled water was used, for group 2 - 20 mL of slurry of toothpaste mixed with artificial saliva, and for group 3 - 20 mL of slurry of toothpaste (BioMin F) mixed with artificial saliva. The micro-hardness data (VHN - Vickers hardness number) was collected at baseline (sound enamel), post-demineralization and post-remineralization.
The biggest difference between the post-remineralization and post-demineralization values was observed in group 3 (mean VHN = 118.73), followed by group 2 (mean VHN = 60.54) and group 1 (mean VHN = 47.44). All the groups revealed significant differences (p < 0.05) when the post-demineralization and post-remineralization values were compared to baseline values within each group.
The BioMin F group outperformed the other 2 groups in terms of remineralizing the demineralized enamel structure.
具有能将矿物质重新补充到早期龋损中这种新成分的牙膏的再矿化潜力，迄今为止尚未得到广泛研究。
本研究的目的是评估一种基于新型含氟生物活性玻璃的牙膏对人牙釉质人工龋损进行再矿化的效果，并将其与标准含氟牙膏进行比较。
将24颗拔除的人牙在牙骨质牙釉质交界处切片以获得牙釉质块。这些块（n = 24）被随机分为3组，每组包含8个样本：第1组（阴性对照组；蒸馏水），第2组（阳性对照组；含氟牙膏）和第3组（试验组；BioMinTM F牙膏）。通过将牙釉质表面暴露于脱矿溶液（6％柠檬酸，pH 2.2）96小时，在牙釉质表面产生人工龋损。脱矿后，在牙刷模拟机中用手动牙刷刷洗样本（每个样本接受800次刷毛运动）。对于刷洗第1组的样本，使用20 mL蒸馏水，对于第2组 - 使用20 mL与人工唾液混合的牙膏糊剂，对于第3组 - 使用20 mL与人工唾液混合的牙膏（BioMin F）糊剂。在基线（完好牙釉质）、脱矿后和再矿化后收集显微硬度数据（维氏硬度值 - VHN）。
在第3组中观察到再矿化后和脱矿后值之间的最大差异（平均VHN = 118.73），其次是第2组（平均VHN = 60.54）和第1组（平均VHN = 47.44）。当将每组内脱矿后和再矿化后的值与基线值进行比较时，所有组均显示出显著差异（p < 0.05）。
在使脱矿的牙釉质结构再矿化方面，BioMin F组优于其他两组。
