Department of Animal Medicine (Internal Medicine), Faculty of Veterinary Medicine, Suez Canal University, Ismailia, 41522, Egypt.
Laboratory of Veterinary Surgery, Tokyo University of Agriculture and Technology, Tokyo, 183-8509, Japan.
Environ Sci Pollut Res Int. 2020 Jun;27(16):19447-19460. doi: 10.1007/s11356-020-08294-2. Epub 2020 Mar 25.
In this study, the influence of supra-nutritional organic selenium (Se) supplement on hematology and plasma biochemicals, including antioxidant parameters and plasma reproductive hormones, as well as blood flow characteristics in the supratesticular and common carotid arteries (STA and CCA, respectively) were investigated. For this purpose, 15 male goats were used and classified into three equal groups according to the supplementation of the basal diet (BD): negative control (NC), probiotic (Pro), and Se-probiotic (Se-Pro) groups. Blood perfusion in the STA and CCA was assessed by Doppler ultrasonography at three different time intervals: at the experimental onset (T0), 3 weeks of dietary supplement (T3), and after 6 weeks of observation (T6). Concomitantly, blood samples were withdrawn for hematobiochemical and hormonal changes. Results revealed no evidence of clinical abnormality, with some enhanced hematological parameters and antioxidant (SOD and GPX) levels in goats of the Se-Pro and Pro groups. High concentrations of FSH were found in the Se-Pro at T6 compared to its values in other groups. Similarly, testosterone levels were elevated in the Pro and Se-Pro groups at T3 compared to other time points. There were significant increases in levels of IGF-1 in the Pro and Se-Pro groups compared to the NC group. Significant (P < 0.05) increases in the values of the blood volume within the CCA and the STA were noted in the Se-Pro group, and the highest values were observed at T6 (CCA, 427.4 ± 33 ml/min; STA, 49.9 ± 5.0 ml/min). In conclusion, supra-nutritional organic selenium improves some hematobiochemical parameters, reproductive hormones, and the blood perfusion within the CCA and STA in goats.
本研究旨在探讨超营养有机硒（Se）补充对血液学和血浆生化指标的影响，包括抗氧化参数和血浆生殖激素，以及睾丸上动脉（STA）和颈总动脉（CCA）的血流特征。为此，使用 15 只雄性山羊，并根据基础日粮（BD）的补充分为三组：阴性对照组（NC）、益生菌（Pro）和 Se-益生菌（Se-Pro）组。在三个不同时间间隔（实验开始时（T0）、补充饮食 3 周（T3）和观察 6 周后（T6））通过多普勒超声评估 STA 和 CCA 的血液灌注。同时，采集血液样本以检测血液生化和激素变化。结果表明，Se-Pro 和 Pro 组的山羊没有出现临床异常迹象，一些血液学参数和抗氧化（SOD 和 GPX）水平增强。与其他组相比，T6 时 Se-Pro 组的 FSH 浓度较高。同样，T3 时 Pro 和 Se-Pro 组的睾酮水平高于其他时间点。与 NC 组相比，Pro 和 Se-Pro 组的 IGF-1 水平显著升高。与 NC 组相比，Se-Pro 组的 CCA 和 STA 内血流量值显著增加（P<0.05），T6 时值最高（CCA：427.4±33ml/min；STA：49.9±5.0ml/min）。综上所述，超营养有机硒可改善山羊的一些血液生化参数、生殖激素以及 CCA 和 STA 的血流灌注。
