Hellgren Roxanna, Saracco Ariel, Strand Fredrik, Eriksson Mikael, Sundbom Ann, Hall Per, Dickman Paul W
Department of Medical Imaging, Division of Breast Imaging, Södersjukhuset, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Acta Radiol. 2020 Dec;61(12):1600-1607. doi: 10.1177/0284185120911583. Epub 2020 Mar 26.
Background parenchymal enhancement (BPE) of normal tissue at breast magnetic resonance imaging is suggested to be an independent risk factor for breast cancer. Its association with established risk factors for breast cancer is not fully investigated.
To study the association between BPE and risk factors for breast cancer in a healthy, non-high-risk screening population.
We measured BPE and mammographic density and used data from self-reported questionnaires in 214 healthy women aged 43-74 years. We estimated odds ratios for the univariable association between BPE and risk factors. We then fitted an adjusted model using logistic regression to evaluate associations between BPE (high vs. low) and risk factors, including mammographic breast density.
The majority of women had low BPE (84%). In a multivariable model, we found statistically significant associations between BPE and age ( = 0.002) and BMI ( = 0.03). We did find a significant association between systemic progesterone medication and BPE, but due to small numbers, the results should be interpreted with caution. The adjusted odds ratio for high BPE was 3.1 among women with density D (compared to B) and 2.1 for density C (compared to B). However, the association between high BPE and density was not statistically significant. We did not find statistically significant associations with any other risk factors.
Our study confirmed the known association of BPE with age and BMI. Although our results show a higher likelihood for high BPE with increasing levels of mammographic density, the association was not statistically significant.
乳腺磁共振成像中正常组织的背景实质强化（BPE）被认为是乳腺癌的一个独立危险因素。其与已确定的乳腺癌危险因素之间的关联尚未得到充分研究。
研究健康、非高危筛查人群中BPE与乳腺癌危险因素之间的关联。
我们测量了214名年龄在43 - 74岁的健康女性的BPE和乳腺钼靶密度，并使用了自我报告问卷中的数据。我们估计了BPE与危险因素之间单变量关联的比值比。然后我们使用逻辑回归拟合一个调整模型，以评估BPE（高与低）与危险因素之间的关联，包括乳腺钼靶密度。
大多数女性的BPE较低（84%）。在多变量模型中，我们发现BPE与年龄（P = 0.002）和体重指数（P = 0.03）之间存在统计学显著关联。我们确实发现全身孕激素用药与BPE之间存在显著关联，但由于数量较少，结果应谨慎解释。密度为D的女性（与B相比）高BPE的调整比值比为3.1，密度为C的女性（与B相比）为2.1。然而，高BPE与密度之间的关联在统计学上并不显著。我们未发现与任何其他危险因素存在统计学显著关联。
我们的研究证实了BPE与年龄和体重指数之间已知的关联。尽管我们的结果显示随着乳腺钼靶密度水平的增加，高BPE的可能性更高，但这种关联在统计学上并不显著。
