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通过为孕妇及其家庭接种疫苗来减少低收入国家的呼吸道合胞病毒（RSV）住院率。

Reducing respiratory syncytial virus (RSV) hospitalization in a lower-income country by vaccinating mothers-to-be and their households.

机构信息

Zeeman Institute of Systems Biology and Infectious Disease Research (SBIDER), University of Warwick, Warwick, United Kingdom.

School of Life Sciences, University of Warwick, Coventry, United Kingdom.

出版信息

Elife. 2020 Mar 27;9:e47003. doi: 10.7554/eLife.47003.

DOI:10.7554/eLife.47003
PMID:32216871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7556875/
Abstract

Respiratory syncytial virus is the leading cause of lower respiratory tract infection among infants. RSV is a priority for vaccine development. In this study, we investigate the potential effectiveness of a two-vaccine strategy aimed at mothers-to-be, thereby boosting maternally acquired antibodies of infants, and their household cohabitants, further cocooning infants against infection. We use a dynamic RSV transmission model which captures transmission both within households and communities, adapted to the changing demographics and RSV seasonality of a low-income country. Model parameters were inferred from past RSV hospitalisations, and forecasts made over a 10-year horizon. We find that a 50% reduction in RSV hospitalisations is possible if the maternal vaccine effectiveness can achieve 75 days of additional protection for newborns combined with a 75% coverage of their birth household co-inhabitants (~7.5% population coverage).

摘要

呼吸道合胞病毒是婴儿下呼吸道感染的主要原因。RSV 是疫苗开发的重点。在这项研究中，我们研究了一种针对孕妇的两剂疫苗策略的潜在效果，从而提高婴儿及其家庭同住者的母婴获得性抗体，进一步保护婴儿免受感染。我们使用了一种动态 RSV 传播模型，该模型可以捕捉家庭和社区内的传播，适应低收入国家人口结构和 RSV 季节性变化。模型参数是根据过去 RSV 住院情况推断出来的，并在 10 年的时间内进行了预测。我们发现，如果母亲疫苗的有效性能够为新生儿提供 75 天的额外保护，同时为新生儿家庭同住者（约 7.5%的人口）提供 75%的覆盖率，那么 RSV 住院率可能会降低 50%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45b4/7556875/c2878f79ff46/elife-47003-app4-fig2.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45b4/7556875/c2878f79ff46/elife-47003-app4-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45b4/7556875/7dbdb3cf56e1/elife-47003-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45b4/7556875/f75514d09c50/elife-47003-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45b4/7556875/0d54bfc9033f/elife-47003-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45b4/7556875/0d00501f9b36/elife-47003-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45b4/7556875/a47c2483d103/elife-47003-fig5.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45b4/7556875/93bb9253e58a/elife-47003-app1-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45b4/7556875/18d8c2cab346/elife-47003-app2-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45b4/7556875/0759c2316c08/elife-47003-app2-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45b4/7556875/fb7ef5a0411e/elife-47003-app2-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45b4/7556875/ff967a0e7d00/elife-47003-app2-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45b4/7556875/9c61712d28db/elife-47003-app2-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45b4/7556875/f305e284ae60/elife-47003-app3-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45b4/7556875/8d1e99c8c064/elife-47003-app3-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45b4/7556875/4a11d5a9467e/elife-47003-app3-fig3.jpg
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