J Clin Invest. 2020 May 1;130(5):2202-2205. doi: 10.1172/JCI137647.
The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10, and TNF-α), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFN-γ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design.
由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）引起的大流行冠状病毒传染病（COVID-19）正在全球迅速蔓延。在本期 JCI 中，Chen 及其同事比较了中度和重度 COVID-19 的临床和免疫学特征。作者发现入院时的呼吸窘迫与不良结局相关。细胞因子水平升高（IL-6、IL-10 和 TNF-α）、淋巴细胞减少（CD4+和 CD8+T 细胞）以及 CD4+T 细胞中 IFN-γ表达降低与严重 COVID-19 相关。总的来说，这项研究描述了严重 COVID-19 中的细胞因子风暴，并为免疫治疗和疫苗设计提供了思路。
