Yu Tao, Wei Qingshan
Department of Chemical and Biomolecular Engineering, North Carolina State University, 911 Partners Way, Campus Box 7905, Raleigh, NC 27695 USA.
Nano Res. 2018;11(10):5439-5473. doi: 10.1007/s12274-018-2094-9. Epub 2018 Jun 5.
Plasmonics-based biosensing assays have been extensively employed for biomedical applications. Significant advancements in use of plasmonic assays for the construction of point-of-care (POC) diagnostic methods have been made to provide effective and urgent health care of patients, especially in resourcelimited settings. This rapidly progressive research area, centered on the unique surface plasmon resonance (SPR) properties of metallic nanostructures with exceptional absorption and scattering abilities, has greatly facilitated the development of cost-effective, sensitive, and rapid strategies for disease diagnostics and improving patient healthcare in both developed and developing worlds. This review highlights the recent advances and applications of plasmonic technologies for highly sensitive protein and nucleic acid biomarker detection. In particular, we focus on the implementation and penetration of various plasmonic technologies in conventional molecular diagnostic assays, and discuss how such modification has resulted in simpler, faster, and more sensitive alternatives that are suited for point-of-use. Finally, integration of plasmonic molecular assays with various portable POC platforms for mobile health applications are highlighted.
基于等离子体激元的生物传感检测方法已广泛应用于生物医学领域。在利用等离子体激元检测构建即时检测（POC）诊断方法方面已取得显著进展，以提供对患者的有效和紧急医疗护理，尤其是在资源有限的环境中。这个快速发展的研究领域以具有特殊吸收和散射能力的金属纳米结构的独特表面等离子体共振（SPR）特性为核心，极大地促进了在发达国家和发展中国家开发具有成本效益、灵敏且快速的疾病诊断策略以及改善患者医疗护理的进程。本综述重点介绍了等离子体激元技术在高灵敏度蛋白质和核酸生物标志物检测方面的最新进展和应用。特别是，我们关注各种等离子体激元技术在传统分子诊断检测中的实施和渗透，并讨论这种改进如何产生了更简单、更快且更灵敏的适用于即时使用的替代方法。最后，强调了将等离子体激元分子检测与各种用于移动健康应用的便携式POC平台进行整合。
