Lu Rong, Ni Jiankun, Yin Shengnan, Ji Yiding
Suzhou Ninth People's Hospital, Suzhou, China.
Front Chem. 2021 Mar 18;9:652287. doi: 10.3389/fchem.2021.652287. eCollection 2021.
Plasmonic nanostructures, particularly of noble-metal Au and Ag, have attracted long-lasting research interests because of their intriguing physical and chemical properties. Under light excitation, their conduction electrons can form collective oscillation with the electromagnetic fields at particular wavelength, leading to localized surface plasmon resonance (LSPR). The remarkable characteristic of LSPR is the absorption and scattering of light at the resonant wavelength and greatly enhanced electric fields in localized areas. In response to the chemical and physical changes, these optical properties of plasmonic nanostructures will exhibit drastic color changes and highly sensitive peak shifts, which has been extensively used for biological imaging and disease treatments. In this mini review, we aim to briefly summarize recent progress of preparing responsive plasmonic nanostructures for biodiagnostics, with specific focus on cancer imaging and treatment. We start with typical synthetic approaches to various plasmonic nanostructures and elucidate practical strategies and working mechanism in tuning their LSPR properties. Current achievements in using responsive plasmonic nanostructures for advanced cancer diagnostics will be further discussed. Concise perspectives on existing challenges in developing plasmonic platforms for clinic diagnostics is also provided at the end of this review.
等离子体纳米结构，特别是贵金属金和银的纳米结构，因其引人入胜的物理和化学性质而吸引了长期的研究兴趣。在光激发下，它们的传导电子可以与特定波长的电磁场形成集体振荡，从而导致局域表面等离子体共振（LSPR）。LSPR的显著特征是在共振波长处对光的吸收和散射以及局部区域中电场的极大增强。响应化学和物理变化，等离子体纳米结构的这些光学性质将表现出剧烈的颜色变化和高度敏感的峰位移，这已被广泛用于生物成像和疾病治疗。在本综述中，我们旨在简要总结用于生物诊断的响应性等离子体纳米结构的最新进展，特别关注癌症成像和治疗。我们从各种等离子体纳米结构的典型合成方法开始，阐明调节其LSPR性质的实际策略和工作机制。将进一步讨论使用响应性等离子体纳米结构进行先进癌症诊断的当前成果。在本综述末尾还提供了关于开发用于临床诊断的等离子体平台中现有挑战的简要观点。
