Lambert Elton M, Gunn G Brandon, Gidley Paul W
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Head Neck. 2016 Sep;38(9):1428-35. doi: 10.1002/hed.24267. Epub 2016 Jul 25.
Radiotherapy is a key component in the treatment of many head and neck cancers, and its potential to cause long-term adverse effects has become increasingly recognized. In this review, we describe the short-term and long-term sequelae of radiation-associated changes in and injury to the temporal bone and its related structures. The pathophysiology of radiation-induced injury and its clinical entities, including sensorineural hearing loss, chronic otitis media, osteoradionecrosis, and radiation-associated malignancies, are described. We also discuss radiation dose to the head and neck as it relates to these conditions. An improved understanding of radiation's effects on the temporal bone will enable physicians and researchers to continue efforts to reduce radiotherapy-related sequelae and guide clinicians in diagnosing and treating the various otologic conditions that can arise in patients with head and neck cancer who have received radiotherapy. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1428-1435, 2016.
放射治疗是许多头颈癌治疗的关键组成部分，其导致长期不良反应的可能性已得到越来越多的认识。在本综述中，我们描述了颞骨及其相关结构辐射相关变化和损伤的短期和长期后遗症。阐述了辐射诱导损伤的病理生理学及其临床实体，包括感音神经性听力损失、慢性中耳炎、放射性骨坏死和辐射相关恶性肿瘤。我们还讨论了与这些病症相关的头颈部辐射剂量。对头颈部放疗的改进理解将使医生和研究人员能够继续努力减少放疗相关后遗症，并指导临床医生诊断和治疗接受过头颈部放疗的患者可能出现的各种耳科病症。© 2016 Wiley Periodicals, Inc. Head Neck 38: 1428 - 1435, 2016.
