Laboratory of Epithelial Biology, Department of Periodontics & Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA.
Laboratory of Oral Histopathology, Health Sciences Faculty, University of Brasília, Brasília, Brazil.
Regen Med. 2020 Feb;15(2):1329-1344. doi: 10.2217/rme-2019-0065. Epub 2020 Mar 30.
Although the human body can heal, it takes time, and slow healing and chronic wounds often occur. Thus, identifying novel therapies to aid regeneration is needed. Here, we conducted a systematic review following the Preferred Reporting Items for Systematic Reviews guidelines and assessed preclinical studies on phosphatase and tensin homolog (PTEN) inhibitors and their effects on tissue repair and regeneration. In conditions associated with neurodegeneration, tissue injury and ischemia, the PTEN-regulated PI3K/AKT signaling pathway is activated. The use of PTEN inhibitors resulted in better tissue response by reducing the healing time and lesion sizes or inducing neuronal regeneration. Notably, all studies included in this systematic review indicated that pharmacological inhibition of PTEN enhanced the repair process of the eye, lung, muscle and nervous system.
虽然人体可以自我修复，但这需要时间，而且伤口愈合缓慢和慢性伤口很常见。因此，需要寻找新的治疗方法来促进组织再生。在这里，我们按照系统评价的首选报告项目指南进行了系统评价，并评估了磷酸酶和张力蛋白同源物 (PTEN) 抑制剂及其对组织修复和再生影响的临床前研究。在与神经退行性变、组织损伤和缺血相关的情况下，PTEN 调节的 PI3K/AKT 信号通路被激活。使用 PTEN 抑制剂可以通过减少愈合时间和病变大小或诱导神经元再生来改善组织反应。值得注意的是，本系统评价中包含的所有研究都表明，PTEN 的药理学抑制增强了眼睛、肺部、肌肉和神经系统的修复过程。
