Pharmaceutical Nanotechnology Laboratory, Universidade Estadual do Centro-Oeste, Alameda Élio Antonio Dalla Vecchia, 838 - CEP 85040-167, Guarapuava-PR, Brazil.
Helmholtz Center for Infection Research, Chemical Microbiology, Inhoffenstraße 7, 38124 Braunschweig, Germany.
Curr Med Chem. 2021;28(9):1841-1873. doi: 10.2174/0929867327666200330143338.
Fungal infections are diseases that are considered neglected although their infection rates have increased worldwide in the last decades. Thus, since the antifungal arsenal is restricted and many strains have shown resistance, new therapeutic alternatives are necessary. Nanoparticles are considered important alternatives to promote drug delivery. In this sense, the objective of the present study was to evaluate the contributions of newly developed nanoparticles to the treatment of fungal infections. Studies have shown that nanoparticles generally improve the biopharmaceutical and pharmacokinetic characteristics of antifungals, which is reflected in a greater pharmacodynamic potential and lower toxicity, as well as the possibility of prolonged action. It also offers the proposition of new routes of administration. Nanotechnology is known to contribute to a new drug delivery system, not only for the control of infectious diseases but for various other diseases as well. In recent years, several studies have emphasized its application in infectious diseases, presenting better alternatives for the treatment of fungal infections.
真菌感染被认为是被忽视的疾病，尽管在过去几十年中，它们在全球的感染率有所上升。因此，由于抗真菌药物的储备有限，并且许多菌株已经表现出耐药性，因此需要新的治疗选择。纳米颗粒被认为是促进药物递送的重要替代品。在这方面，本研究的目的是评估新开发的纳米颗粒对治疗真菌感染的贡献。研究表明，纳米颗粒通常可以改善抗真菌药物的生物制药和药代动力学特性，这反映在更大的药效潜力和更低的毒性，以及延长作用的可能性。它还提供了新的给药途径的建议。纳米技术有望为新的药物输送系统做出贡献，不仅可以控制传染病，还可以用于治疗各种其他疾病。近年来，多项研究强调了其在传染病中的应用，为治疗真菌感染提供了更好的替代方案。
